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Kng2 Gene Detail
Summary
  • Symbol
    Kng2
  • Name
    kininogen 2
  • Synonyms
    Kininogen-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027157
    NCBI Gene: 385643
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22804602-22847851 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1328 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027157
 protein coding gene Chr16:22804602-22848232 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022638
 protein coding gene Chr16:19540841-19567377 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0022643
 protein coding gene Chr16:19726135-19777314 (-)
C3H/HeJ MGP_C3HHeJ_G0022407
 protein coding gene Chr16:20445067-20522066 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0021937
 protein coding gene Chr16:20437115-20496775 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022487
 protein coding gene Chr16:19476344-19537381 (-)
LP/J MGP_LPJ_G0022579
 protein coding gene Chr16:20282982-20359679 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022506
 protein coding gene Chr16:21386601-21451237 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023104
 protein coding gene Chr16:20278744-20347284 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021980
 protein coding gene Chr16:20254441-20310685 (-)



Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KNG1, kininogen 1
  • Synonyms
    BDK, BK, HAE6, HK, HMWK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042
    UniProt: P01042

  • Chr Location
    3q27.3; chr3:186717348-186744410 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KNG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    51
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 385643 NCBI Gene Model | MGI Sequence Detail 43250 C57BL/6J ±  kb
    transcript NM_201375 RefSeq | MGI Sequence Detail 2305 C57BL/6  
    polypeptide NP_958763 RefSeq | MGI Sequence Detail 644 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR000010 Cystatin domain
      IPR046350 Cystatin superfamily
      IPR002395 HMW kininogen
      IPR050735 Kininogen/Fetuin/Histidine-rich Glycoprotein
      IPR027358 Kininogen-type cystatin domain
      IPR018073 Proteinase inhibitor I25, cystatin, conserved site
    • GlyGen
      Q6S9I3 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 2
      cDNA 51

      Microarray probesets 1
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:90550 Cardoso CC, et al., Structure and expression of two kininogen genes in mice. Biol Chem. 2004 Mar-Apr;385(3-4):295-301
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory