Lrrc4b MGI Mouse Gene Detail - MGI:3027390 - leucine rich repeat containing 4B

Symbol

Lrrc4b
Name

leucine rich repeat containing 4B
Synonyms

Lrig4, Ngl3, NGL-3

Feature Type

protein coding gene
IDs

MGI:3027390
NCBI Gene: 272381
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:44091911-44112775 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 28.83 cM
Mapping Data

1 experiment

SNPs within 2kb

462 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3027390	protein coding gene	Chr7:44078442-44112775 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032161	protein coding gene	Chr7:44600147-44634059 (+)
A/J	MGP_AJ_G0032140	protein coding gene	Chr7:43782998-43818720 (+)
AKR/J	MGP_AKRJ_G0032076	protein coding gene	Chr7:44985187-45021204 (+)
BALB/cJ	MGP_BALBcJ_G0032152	protein coding gene	Chr7:43779679-43815128 (+)
C3H/HeJ	MGP_C3HHeJ_G0031868	protein coding gene	Chr7:45475357-45512409 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032644	protein coding gene	Chr7:46848470-46890036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029658	protein coding gene	Chr7:46371615-46404604 (+)
CAST/EiJ	MGP_CASTEiJ_G0031196	protein coding gene	Chr7:36845521-36887535 (+)
CBA/J	MGP_CBAJ_G0031832	protein coding gene	Chr7:48375773-48413256 (+)
DBA/2J	MGP_DBA2J_G0031990	protein coding gene	Chr7:43458222-43492881 (+)
FVB/NJ	MGP_FVBNJ_G0031941	protein coding gene	Chr7:43188990-43225897 (+)
LP/J	MGP_LPJ_G0032068	protein coding gene	Chr7:45278556-45316341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031978	protein coding gene	Chr7:47127065-47162959 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032660	protein coding gene	Chr7:44201895-44235671 (+)
PWK/PhJ	MGP_PWKPhJ_G0030919	protein coding gene	Chr7:36801248-36837813 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030756	protein coding gene	Chr7:32209892-32245488 (+)
WSB/EiJ	MGP_WSBEiJ_G0031313	protein coding gene	Chr7:44662830-44698212 (+)

Human Ortholog

LRRC4B, leucine rich repeat containing 4B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC4B, leucine rich repeat containing 4B
Synonyms

HSM, LRIG4, NGL-3
Links

HGNC:25042

NCBI Gene ID: 94030

neXtProt AC: NX_Q9NT99

UniProt: Q9NT99
Chr Location

19q13.33; chr19:50516892-50568435 (-) GRCh38

MGI Vertebrate Homology

Lrrc4b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LRRC4B
Gene Tree

Lrrc4b

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Phenotype Summary

34 phenotypes from 2 alleles in 3 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired brain development and impaired long-term depression, and locomotive and cognitive behaviors in a background strain manner.

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

24
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc4b

ZFIN lrrc4ba

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS21206.1

Ensembl

ENSMUSG00000047085 (Evidence)
NCBI Gene

272381

			Length	Strain/Species	Flank
genomic	272381	NCBI Gene Model \| MGI Sequence Detail	20865	C57BL/6J	± kb
transcript	NM_198250	RefSeq \| MGI Sequence Detail	2753	C57BL/6
polypeptide	P0C192	UniProt \| EBI \| MGI Sequence Detail	709	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029602 leucine-rich repeat-containing protein 4B

(term hierarchy)
PDB

3ZYN, 3ZYO
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR050541 Leucine-rich repeat and transmembrane domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

P0C192 10 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 30

cDNA 28

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 4
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrc4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66156	Chr7:44091139-44091180 (+)	-751 bp
Tssr66157	Chr7:44091391-44091396 (+)	-517 bp
Tssr66158	Chr7:44091413-44091446 (+)	-481 bp
Tssr66159	Chr7:44091447-44091462 (+)	-456 bp
Tssr66160	Chr7:44091493-44091504 (+)	-412 bp
Tssr66161	Chr7:44091822-44091849 (+)	-75 bp
Tssr66162	Chr7:44111545-44111589 (+)	19,656 bp
Tssr66163	Chr7:44112447-44112471 (+)	20,548 bp
Tssr66164	Chr7:44112533-44112535 (+)	20,623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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