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Adamtsl3 Gene Detail
Summary
  • Symbol
    Adamtsl3
  • Name
    ADAMTS-like 3
  • Synonyms
    9230119C12Rik, punctin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028499
    NCBI Gene: 269959
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81984902-82263658 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 47.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7987 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028499
 protein coding gene Chr7:81984612-82263658 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032443
 protein coding gene Chr7:84438733-84741408 (+)
A/J MGP_AJ_G0032421
 protein coding gene Chr7:82426539-82704746 (+)
AKR/J MGP_AKRJ_G0032357
 protein coding gene Chr7:84279033-84575937 (+)
BALB/cJ MGP_BALBcJ_G0032433
 protein coding gene Chr7:82086274-82366206 (+)
C3H/HeJ MGP_C3HHeJ_G0032147
 protein coding gene Chr7:84862208-85152097 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032924
 protein coding gene Chr7:87726675-88033402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029934
 protein coding gene Chr7:84867004-85137225 (+)
CAST/EiJ MGP_CASTEiJ_G0031474
 protein coding gene Chr7:75819195-76118060 (+)
CBA/J MGP_CBAJ_G0032112
 protein coding gene Chr7:90640959-90962685 (+)
DBA/2J MGP_DBA2J_G0032267
 protein coding gene Chr7:80946409-81225023 (+)
FVB/NJ MGP_FVBNJ_G0032221
 protein coding gene Chr7:80895289-81174147 (+)
LP/J MGP_LPJ_G0032348
 protein coding gene Chr7:85659686-85953618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032258
 protein coding gene Chr7:90696873-91005770 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032944
 protein coding gene Chr7:83684158-83989047 (+)
PWK/PhJ MGP_PWKPhJ_G0031194
 protein coding gene Chr7:74164237-74445389 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031036
 protein coding gene Chr7:70651883-70971195 (+)
WSB/EiJ MGP_WSBEiJ_G0031591
 protein coding gene Chr7:84045287-84347712 (+)



Homology
more
  • Human Ortholog
    ADAMTSL3, ADAMTS like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTSL3, ADAMTS like 3
  • Synonyms
    ADAMTSL-3
  • Links
    NCBI Gene ID: 57188
    neXtProt AC: NX_P82987
    UniProt: P82987

  • Chr Location
    15q25.2; chr15:83654088-84039842 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased heart weight, longer tibia bones, and exacerbated cardiac dilatation and contractile dysfunction as well as higher mortality in response to pressure overload.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070469 Ensembl Gene Model | MGI Sequence Detail 278757 C57BL/6J ±  kb
    transcript ENSMUST00000173287 Ensembl | MGI Sequence Detail 7249 Not Applicable  
    polypeptide ENSMUSP00000133637 Ensembl | MGI Sequence Detail 1706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1925159
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory