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Rasgrp3 Gene Detail
Summary
  • Symbol
    Rasgrp3
  • Name
    RAS, guanyl releasing protein 3
  • Synonyms
    LOC240168, MGC:74365
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028579
    NCBI Gene: 240168
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:75742891-75836049 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 46.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028579
 protein coding gene Chr17:75742849-75836049 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024034
 protein coding gene Chr17:78143797-78243200 (+)
A/J MGP_AJ_G0023991
 protein coding gene Chr17:75704664-75802928 (+)
AKR/J MGP_AKRJ_G0023960
 protein coding gene Chr17:76822066-76920750 (+)
BALB/cJ MGP_BALBcJ_G0023993
 protein coding gene Chr17:75611034-75707095 (+)
C3H/HeJ MGP_C3HHeJ_G0023757
 protein coding gene Chr17:77731804-77833545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024438
 protein coding gene Chr17:80934999-81042472 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021882
 protein coding gene Chr17:71312754-71408082 (+)
CAST/EiJ MGP_CASTEiJ_G0023237
 protein coding gene Chr17:78272289-78373129 (+)
CBA/J MGP_CBAJ_G0023731
 protein coding gene Chr17:84331716-84423266 (+)
DBA/2J MGP_DBA2J_G0023860
 protein coding gene Chr17:74275890-74370882 (+)
FVB/NJ MGP_FVBNJ_G0023826
 protein coding gene Chr17:73819319-73913285 (+)
LP/J MGP_LPJ_G0023943
 protein coding gene Chr17:78902299-79006995 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023854
 protein coding gene Chr17:84099587-84205221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024482
 protein coding gene Chr17:77298877-77398608 (+)
PWK/PhJ MGP_PWKPhJ_G0022983
 protein coding gene Chr17:73698435-73794215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022794
 protein coding gene Chr17:74039566-74143413 (+)
WSB/EiJ MGP_WSBEiJ_G0023304
 protein coding gene Chr17:78168783-78271113 (+)



Homology
more
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
  • Synonyms
    GRP3
  • Links
    NCBI Gene ID: 25780
    neXtProt AC: NX_Q8IV61
    UniProt: Q8IV61

  • Chr Location
    2p22.3; chr2:33436324-33564750 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RASGRP3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile with no obvious abnormalities in the kidneys or vasculature.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    4
  • cDNA Data
    7
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071042 Ensembl Gene Model | MGI Sequence Detail 93159 C57BL/6J ±  kb
    transcript ENSMUST00000164192 Ensembl | MGI Sequence Detail 4655 Not Applicable  
    polypeptide ENSMUSP00000129393 Ensembl | MGI Sequence Detail 691 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2685173
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:94466 Aiba Y, et al., Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory