Zfp281 MGI Mouse Gene Detail - MGI:3029290

Symbol

Zfp281
Name

zinc finger protein 281
Synonyms

MGC:70044, MGC:7737

Feature Type

protein coding gene
IDs

MGI:3029290
NCBI Gene: 226442
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:136552639-136557791 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.93 cM
Mapping Data

1 experiment

SNPs within 2kb

66 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3029290	protein coding gene	Chr1:136552639-136558129 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016543	protein coding gene	Chr1:140482922-140488074 (+)
A/J	MGP_AJ_G0016526	protein coding gene	Chr1:135136032-135141184 (+)
AKR/J	MGP_AKRJ_G0016491	protein coding gene	Chr1:139164333-139169485 (+)
BALB/cJ	MGP_BALBcJ_G0016486	protein coding gene	Chr1:135479094-135484246 (+)
C3H/HeJ	MGP_C3HHeJ_G0016312	protein coding gene	Chr1:139260031-139265183 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016947	protein coding gene	Chr1:145482829-145487981 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014658	protein coding gene	Chr1:128247357-128252492 (+)
CAST/EiJ	MGP_CASTEiJ_G0015892	protein coding gene	Chr1:138372127-138377283 (+)
CBA/J	MGP_CBAJ_G0016285	protein coding gene	Chr1:150519394-150524546 (+)
DBA/2J	MGP_DBA2J_G0016391	protein coding gene	Chr1:134132062-134137224 (+)
FVB/NJ	MGP_FVBNJ_G0016390	protein coding gene	Chr1:132783138-132788290 (+)
LP/J	MGP_LPJ_G0016462	protein coding gene	Chr1:141682650-141687802 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016415	protein coding gene	Chr1:156163362-156168514 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016983	protein coding gene	Chr1:138927711-138932863 (+)
PWK/PhJ	MGP_PWKPhJ_G0015678	protein coding gene	Chr1:133185405-133190526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015465	protein coding gene	Chr1:137918248-137923600 (+)
WSB/EiJ	MGP_WSBEiJ_G0015955	protein coding gene	Chr1:138966288-138971440 (+)

Human Ortholog

ZNF281, zinc finger protein 281

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF281, zinc finger protein 281
Synonyms

GZP1, ZBP-99, ZBP99, ZNP-99
Links

HGNC:13075

NCBI Gene ID: 23528

neXtProt AC: NX_Q9Y2X9

UniProt: Q9Y2X9
Chr Location

1q32.1; chr1:200404940-200410056 (-) GRCh38

MGI Vertebrate Homology

Zfp281 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZNF281
Gene Tree

Zfp281

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Zfp281
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5.

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All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

66
cDNA Data

10
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf281b

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS15327.1

Ensembl

ENSMUSG00000041483 (Evidence)
NCBI Gene

226442

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041483	Ensembl Gene Model \| MGI Sequence Detail	5153	C57BL/6J	± kb
transcript	ENSMUST00000047734	Ensembl \| MGI Sequence Detail	4933	Not Applicable
polypeptide	ENSMUSP00000039003	Ensembl \| MGI Sequence Detail	893	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017804 zinc finger protein 281

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q99LI5 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (7 sites)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 4

Summaries

All 51

Developmental Gene Expression 11

Gene Ontology 9

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:346060 Huang X, et al., ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Dev Cell. 2024 Feb 26;59(4):465-481.e6

TSS for Zfp281:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9074	Chr1:136552671-136552687 (+)	40 bp
Tssr9075	Chr1:136552689-136552733 (+)	72 bp
Tssr9076	Chr1:136552735-136552758 (+)	108 bp
Tssr9077	Chr1:136553832-136553877 (+)	1,216 bp
Tssr9078	Chr1:136555537-136555559 (+)	2,909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24