Med13 MGI Mouse Gene Detail - MGI:3029632 - mediator complex subunit 13

Symbol

Med13
Name

mediator complex subunit 13
Synonyms

1110067M05Rik, Thrap1, Trap240

Feature Type

protein coding gene
IDs

MGI:3029632
NCBI Gene: 327987
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr11:86157859-86248422 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.75 cM
Mapping Data

2 experiments

SNPs within 2kb

1453 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3029632	protein coding gene	Chr11:86157859-86248428 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018888	protein coding gene	Chr11:87816157-87908342 (-)
A/J	MGP_AJ_G0018855	protein coding gene	Chr11:84435517-84526018 (-)
AKR/J	MGP_AKRJ_G0018825	protein coding gene	Chr11:86965813-87058367 (-)
BALB/cJ	MGP_BALBcJ_G0018828	protein coding gene	Chr11:84824526-84915127 (-)
C3H/HeJ	MGP_C3HHeJ_G0018642	protein coding gene	Chr11:86993681-87085942 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019280	protein coding gene	Chr11:90478130-90573165 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016913	protein coding gene	Chr11:81466377-81560161 (-)
CAST/EiJ	MGP_CASTEiJ_G0018197	protein coding gene	Chr11:87651374-87748325 (-)
CBA/J	MGP_CBAJ_G0018613	protein coding gene	Chr11:94279138-94375838 (-)
DBA/2J	MGP_DBA2J_G0018721	protein coding gene	Chr11:84009895-84100486 (-)
FVB/NJ	MGP_FVBNJ_G0018710	protein coding gene	Chr11:83513731-83605042 (-)
LP/J	MGP_LPJ_G0018791	protein coding gene	Chr11:88305850-88398837 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018737	protein coding gene	Chr11:94396401-94498483 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019320	protein coding gene	Chr11:87214205-87306109 (-)
PWK/PhJ	MGP_PWKPhJ_G0017966	protein coding gene	Chr11:84799991-84892951 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017758	protein coding gene	Chr11:86756308-86850004 (-)
WSB/EiJ	MGP_WSBEiJ_G0018248	protein coding gene	Chr11:87087481-87178976 (-)

Human Ortholog

MED13, mediator complex subunit 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED13, mediator complex subunit 13
Synonyms

ARC250, DRIP250, HSPC221, MRD61, THRAP1, TRAP240
Links

HGNC:22474

NCBI Gene ID: 9969

neXtProt AC: NX_Q9UHV7

UniProt: Q9UHV7
Chr Location

17q23.2; chr17:61942605-62065278 (-) GRCh38

MGI Vertebrate Homology

Med13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MED13
Gene Tree

Med13

Diseases

1 with human MED13 associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

27 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

12
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Med13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

89 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele exhibited in the heart exhibit increased susceptibility to obesity and worsened glucose intolerance when fed a high fat diet.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

39
cDNA Data

103
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med13

ZFIN med13a, med13b

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS36267.1

Ensembl

ENSMUSG00000034297 (Evidence)
NCBI Gene

327987

			Length	Strain/Species	Flank
genomic	327987	NCBI Gene Model \| MGI Sequence Detail	90564	C57BL/6J	± kb
transcript	NM_001080931	RefSeq \| MGI Sequence Detail	10540	C57BL/6
polypeptide	Q5SWW4	UniProt \| EBI \| MGI Sequence Detail	2171	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010284 mediator of RNA polymerase II transcription subunit 13

(term hierarchy)
PDB

8T1L
InterPro Domains

IPR051139 Mediator complex subunit 13

IPR009401 Mediator complex subunit Med13, C-terminal

IPR041285 MID domain of medPIWI

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All nucleic 107

cDNA 103

Primer pair 4

Microarray probesets 5

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MGI:1916101

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109847	Chr11:86249110-86249148 (-)	-707 bp
Tssr109846	Chr11:86249062-86249085 (-)	-652 bp
Tssr109845	Chr11:86249044-86249053 (-)	-627 bp
Tssr109844	Chr11:86249009-86249020 (-)	-593 bp
Tssr109843	Chr11:86248993-86248998 (-)	-574 bp
Tssr109842	Chr11:86248736-86248748 (-)	-320 bp
Tssr109841	Chr11:86248396-86248440 (-)	4 bp
Tssr109840	Chr11:86248172-86248211 (-)	230 bp
Tssr109839	Chr11:86246955-86246958 (-)	1,465 bp
Tssr109838	Chr11:86242943-86242944 (-)	5,478 bp
Tssr109837	Chr11:86239873-86239874 (-)	8,548 bp
Tssr109836	Chr11:86219343-86219352 (-)	29,074 bp
Tssr109835	Chr11:86197264-86197269 (-)	51,155 bp
Tssr109834	Chr11:86195551-86195565 (-)	52,864 bp
Tssr109833	Chr11:86195520-86195526 (-)	52,899 bp
Tssr109832	Chr11:86191980-86191999 (-)	56,432 bp
Tssr109831	Chr11:86177301-86177308 (-)	71,117 bp
Tssr109830	Chr11:86159374-86159391 (-)	89,039 bp
Tssr109829	Chr11:86158957-86158975 (-)	89,456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24