Garin1b MGI Mouse Gene Detail - MGI:3032524 - golgi associated RAB2 interactor 1B

Symbol

Garin1b
Name

golgi associated RAB2 interactor 1B
Synonyms

Fam71f1, LOC330277

Feature Type

protein coding gene
IDs

MGI:3032524
NCBI Gene: 330277
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:29319139-29336018 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.36 cM
Mapping Data

1 experiment

SNPs within 2kb

609 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3032524	protein coding gene	Chr6:29313468-29336021 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030519	protein coding gene	Chr6:27106926-27123785 (+)
A/J	MGP_AJ_G0030492	protein coding gene	Chr6:25960846-25977727 (+)
AKR/J	MGP_AKRJ_G0030419	protein coding gene	Chr6:26816374-26834702 (+)
BALB/cJ	MGP_BALBcJ_G0030502	protein coding gene	Chr6:26116164-26133042 (+)
C3H/HeJ	MGP_C3HHeJ_G0030215	protein coding gene	Chr6:26813865-26832643 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030956	protein coding gene	Chr6:27891669-27908546 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028167	protein coding gene	Chr6:24168191-24186027 (+)
CAST/EiJ	MGP_CASTEiJ_G0029617	protein coding gene	Chr6:26609843-26628676 (+)
CBA/J	MGP_CBAJ_G0030193	protein coding gene	Chr6:28926984-28943856 (+)
DBA/2J	MGP_DBA2J_G0030337	protein coding gene	Chr6:25903235-25920067 (+)
FVB/NJ	MGP_FVBNJ_G0030291	protein coding gene	Chr6:25662670-25681291 (+)
LP/J	MGP_LPJ_G0030424	protein coding gene	Chr6:27239850-27256886 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030327	protein coding gene	Chr6:31451223-31469142 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030986	protein coding gene	Chr6:26691817-26708696 (+)
PWK/PhJ	MGP_PWKPhJ_G0029331	protein coding gene	Chr6:25438592-25455736 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029167	protein coding gene	Chr6:26413320-26430075 (+)
WSB/EiJ	MGP_WSBEiJ_G0029693	protein coding gene	Chr6:26661795-26679944 (+)

Human Ortholog

GARIN1B, golgi associated RAB2 interactor 1B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GARIN1B, golgi associated RAB2 interactor 1B
Synonyms

FAM137A, FAM71F1, GARI-L1, GARIL1, NYD-SP18
Links

HGNC:30704

NCBI Gene ID: 84691

neXtProt AC: NX_Q96KD3

UniProt: Q96KD3
Chr Location

7q32.1; chr7:128709061-128731743 (+) GRCh38

MGI Vertebrate Homology

Garin1b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GARIN1B
Gene Tree

Garin1b

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility due to abnormal acrosome and impaired acrosome reaction.

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

76
RefSeq

34
UniProt

5
CCDS

CCDS39451.1, CCDS80497.1, CCDS80498.1

Ensembl

ENSMUSG00000039742 (Evidence)
NCBI Gene

330277

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039742	Ensembl Gene Model \| MGI Sequence Detail	16880	C57BL/6J	± kb
transcript	ENSMUST00000164560	Ensembl \| MGI Sequence Detail	1411	Not Applicable
polypeptide	ENSMUSP00000126496	Ensembl \| MGI Sequence Detail	344	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031832 Golgi-associated RAB2 interactor protein 1B

(term hierarchy)
InterPro Domains

IPR022168 Golgi associated RAB2 interactor protein-like, Rab2B-binding domain

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All nucleic 15

cDNA 15

Microarray probesets 2

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MGI:2685610, MGI:6885581

Summaries

All 27

Gene Ontology 1

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Garin1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55233	Chr6:29319132-29319152 (+)	3 bp
Tssr55234	Chr6:29319190-29319193 (+)	53 bp
Tssr55235	Chr6:29319228-29319236 (+)	93 bp
Tssr55236	Chr6:29319245-29319250 (+)	109 bp
Tssr55237	Chr6:29319260-29319271 (+)	127 bp
Tssr55238	Chr6:29319272-29319283 (+)	139 bp
Tssr55239	Chr6:29323287-29323332 (+)	4,171 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24