Slc27a6 MGI Mouse Gene Detail - MGI:3036230 - solute carrier family 27 (fatty acid transporter), member 6

Symbol

Slc27a6
Name

solute carrier family 27 (fatty acid transporter), member 6
Synonyms

4732438L20Rik, FATP6

Feature Type

protein coding gene
IDs

MGI:3036230
NCBI Gene: 225579
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:58689329-58745845 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 33.71 cM
Mapping Data

1 experiment

SNPs within 2kb

2200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036230	protein coding gene	Chr18:58689312-58745941 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024453	protein coding gene	Chr18:58077323-58146415 (+)
A/J	MGP_AJ_G0024419	protein coding gene	Chr18:55750424-55809221 (+)
AKR/J	MGP_AKRJ_G0024389	protein coding gene	Chr18:57280522-57341190 (+)
BALB/cJ	MGP_BALBcJ_G0024419	protein coding gene	Chr18:55902084-55959217 (+)
C3H/HeJ	MGP_C3HHeJ_G0024186	protein coding gene	Chr18:57484016-57550051 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024865	protein coding gene	Chr18:59892272-59955803 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022297	protein coding gene	Chr18:55316657-55376329 (+)
CAST/EiJ	MGP_CASTEiJ_G0023660	protein coding gene	Chr18:57518108-57580588 (+)
CBA/J	MGP_CBAJ_G0024156	protein coding gene	Chr18:61806929-61881401 (+)
DBA/2J	MGP_DBA2J_G0024286	protein coding gene	Chr18:55442764-55498755 (+)
FVB/NJ	MGP_FVBNJ_G0024253	protein coding gene	Chr18:54817941-54877596 (+)
LP/J	MGP_LPJ_G0024371	protein coding gene	Chr18:58003571-58071372 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024283	protein coding gene	Chr18:63347573-63411947 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024912	protein coding gene	Chr18:57412594-57471974 (+)
PWK/PhJ	MGP_PWKPhJ_G0023404	protein coding gene	Chr18:55466407-55525705 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023210	protein coding gene	Chr18:57497034-57562111 (+)
WSB/EiJ	MGP_WSBEiJ_G0023723	protein coding gene	Chr18:57308996-57370383 (+)

Human Ortholog

SLC27A6, solute carrier family 27 member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC27A6, solute carrier family 27 member 6
Synonyms

ACSVL2, FACVL2, FATP6, VLCS-H1
Links

HGNC:11000

NCBI Gene ID: 28965

neXtProt AC: NX_Q9Y2P4

UniProt: Q9Y2P4
Chr Location

5q23.3; chr5:128538013-129033642 (+) GRCh38

MGI Vertebrate Homology

Slc27a6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC27A6
Gene Tree

Slc27a6

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Radiation induced

2
Targeted

2
Genomic Mutations

2 involving Slc27a6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

125
cDNA Data

9
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc27a6

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All Sequences

28
RefSeq

2
UniProt

2
CCDS

CCDS37828.1

Ensembl

ENSMUSG00000024600 (Evidence)
NCBI Gene

225579

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024600	Ensembl Gene Model \| MGI Sequence Detail	56517	C57BL/6J	± kb
transcript	ENSMUST00000025500	Ensembl \| MGI Sequence Detail	2485	Not Applicable
polypeptide	ENSMUSP00000025500	Ensembl \| MGI Sequence Detail	619	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015050 long-chain fatty acid transport protein 6

(term hierarchy)
EC

6.2.1.-, 6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 1

Summaries

All 50

Developmental Gene Expression 13

Diseases 1

Gene Ontology 8

Phenotypes 17
Earliest

J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc27a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151211	Chr18:58689030-58689081 (+)	-273 bp
Tssr151212	Chr18:58689083-58689119 (+)	-228 bp
Tssr151213	Chr18:58689134-58689145 (+)	-189 bp
Tssr151214	Chr18:58689148-58689153 (+)	-178 bp
Tssr151215	Chr18:58689162-58689172 (+)	-162 bp
Tssr151216	Chr18:58689272-58689288 (+)	-49 bp
Tssr151217	Chr18:58689296-58689318 (+)	-22 bp
Tssr151218	Chr18:58705087-58705105 (+)	15,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24