Plcl1 MGI Mouse Gene Detail - MGI:3036262

Symbol

Plcl1
Name

phospholipase C-like 1
Synonyms

C230017K02Rik, PLC-L, PRIP-1

Feature Type

protein coding gene
IDs

MGI:3036262
NCBI Gene: 227120
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:55445080-55793444 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 28.15 cM
Mapping Data

1 experiment

SNPs within 2kb

10042 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036262	protein coding gene	Chr1:55442722-55793444 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016036	protein coding gene	Chr1:55126855-55499952 (+)
A/J	MGP_AJ_G0016019	protein coding gene	Chr1:53222259-53579042 (+)
AKR/J	MGP_AKRJ_G0015975	protein coding gene	Chr1:54669329-55026814 (+)
BALB/cJ	MGP_BALBcJ_G0015974	protein coding gene	Chr1:53261720-53627227 (+)
C3H/HeJ	MGP_C3HHeJ_G0015806	protein coding gene	Chr1:54910362-55276440 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016427	protein coding gene	Chr1:57415348-57809181 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014148	protein coding gene	Chr1:49308988-49632828 (+)
CAST/EiJ	MGP_CASTEiJ_G0015388	protein coding gene	Chr1:54192764-54560539 (+)
CBA/J	MGP_CBAJ_G0015778	protein coding gene	Chr1:59069084-59456140 (+)
DBA/2J	MGP_DBA2J_G0015879	protein coding gene	Chr1:52656930-53008366 (+)
FVB/NJ	MGP_FVBNJ_G0015881	protein coding gene	Chr1:51984533-52329540 (+)
LP/J	MGP_LPJ_G0015951	protein coding gene	Chr1:55974241-56349172 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015901	protein coding gene	Chr1:62148647-62524190 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016474	protein coding gene	Chr1:54610679-54989855 (+)
PWK/PhJ	MGP_PWKPhJ_G0015174	protein coding gene	Chr1:52002064-52358359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014955	protein coding gene	Chr1:54232346-54607537 (+)
WSB/EiJ	MGP_WSBEiJ_G0015451	protein coding gene	Chr1:54297577-54671276 (+)

Human Ortholog

PLCL1, phospholipase C like 1 (inactive)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLCL1, phospholipase C like 1 (inactive)
Synonyms

PLCE, PLCL, PLDL1, PPP1R127, PRIP
Links

HGNC:9063

NCBI Gene ID: 5334

neXtProt AC: NX_Q15111

UniProt: Q15111
Chr Location

2q33.1; chr2:197804593-198572581 (+) GRCh38

MGI Vertebrate Homology

Plcl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLCL1
Gene Tree

Plcl1

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Phenotype Summary

10 phenotypes from 3 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
1 images
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Plcl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants display impaired motor coordination and decreased sensitivity to the sedative diazepam.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

104
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plcl1

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS48263.1

Ensembl

ENSMUSG00000038349 (Evidence)
NCBI Gene

227120

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038349	Ensembl Gene Model \| MGI Sequence Detail	348365	C57BL/6J	± kb
transcript	ENSMUST00000042986	Ensembl \| MGI Sequence Detail	6580	Not Applicable
polypeptide	ENSMUSP00000037854	Ensembl \| MGI Sequence Detail	1096	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012840 inactive phospholipase C-like protein 1

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR011992 EF-hand domain pair

IPR011993 PH-like domain superfamily

IPR000909 Phosphatidylinositol-specific phospholipase C, X domain

IPR001192 Phosphoinositide phospholipase C family

IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain

IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain

IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 20

cDNA 20

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 24
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:327722 Gao J, et al., Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes. J Cell Sci. 2022 Jan 1;135(1):jcs258584

TSS for Plcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6722	Chr1:55445040-55445126 (+)	3 bp
Tssr6723	Chr1:55445155-55445166 (+)	81 bp
Tssr6724	Chr1:55445322-55445402 (+)	282 bp
Tssr89	Chr1:55451371-55451372 (+)	6,292 bp
Tssr6725	Chr1:55489257-55489270 (+)	44,184 bp
Tssr6726	Chr1:55489347-55489379 (+)	44,283 bp
Tssr6727	Chr1:55489458-55489548 (+)	44,423 bp
Tssr6728	Chr1:55495879-55495896 (+)	50,808 bp
Tssr6729	Chr1:55645224-55645228 (+)	200,146 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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