Slc13a5 MGI Mouse Gene Detail - MGI:3037150 - solute carrier family 13 (sodium-dependent citrate transporter), member 5

Symbol

Slc13a5
Name

solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms

Indy, mINDY, NaC2/NaCT, Nact

Feature Type

protein coding gene
IDs

MGI:3037150
NCBI Gene: 237831
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:72132815-72158048 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.95 cM
Mapping Data

2 experiments

SNPs within 2kb

522 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3037150	protein coding gene	Chr11:72132815-72158092 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018634	protein coding gene	Chr11:72860020-72885356 (-)
A/J	MGP_AJ_G0018602	protein coding gene	Chr11:70134454-70161471 (-)
AKR/J	MGP_AKRJ_G0018571	protein coding gene	Chr11:72268604-72297973 (-)
BALB/cJ	MGP_BALBcJ_G0018574	protein coding gene	Chr11:70429898-70454781 (-)
C3H/HeJ	MGP_C3HHeJ_G0018387	protein coding gene	Chr11:72230175-72256032 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019025	protein coding gene	Chr11:75063972-75089316 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016668	protein coding gene	Chr11:66976346-67000939 (-)
CAST/EiJ	MGP_CASTEiJ_G0017942	protein coding gene	Chr11:72578778-72626264 (-)
CBA/J	MGP_CBAJ_G0018359	protein coding gene	Chr11:78386978-78414088 (-)
DBA/2J	MGP_DBA2J_G0018468	protein coding gene	Chr11:69784440-69809568 (-)
FVB/NJ	MGP_FVBNJ_G0018459	protein coding gene	Chr11:69308452-69333663 (-)
LP/J	MGP_LPJ_G0018539	protein coding gene	Chr11:73368686-73393605 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018482	protein coding gene	Chr11:78959528-78984800 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019067	protein coding gene	Chr11:72473946-72498875 (-)
PWK/PhJ	MGP_PWKPhJ_G0017715	protein coding gene	Chr11:70396740-70422313 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017505	protein coding gene	Chr11:72179029-72204566 (-)
WSB/EiJ	MGP_WSBEiJ_G0017996	protein coding gene	Chr11:72210627-72235973 (-)

Human Ortholog

SLC13A5, solute carrier family 13 member 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC13A5, solute carrier family 13 member 5
Synonyms

DEE25, EIEE25, INDY, mIndy, NACT
Links

HGNC:23089

NCBI Gene ID: 284111

neXtProt AC: NX_Q86YT5

UniProt: Q86YT5
Chr Location

17p13.1; chr17:6684719-6713377 (-) GRCh38

MGI Vertebrate Homology

Slc13a5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC13A5
Gene Tree

Slc13a5

Diseases

1 with human SLC13A5 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 25 IDs developmental and epileptic encephalopathy 25 DOID:0080453 OMIM:615905

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 4 alleles in 4 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

9
Genomic Mutations

2 involving Slc13a5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display resistance to diet and age induced obesity, increased energy expenditure, improved glucose tolerance, and increased hepatic lipid oxidation. Mice homozygous for an ENU-induced allele exhibit reduced body weight.

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All GO Annotations

47
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

11
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc13a5

ZFIN slc13a5a

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All Sequences

59
RefSeq

14
UniProt

6
CCDS

CCDS24983.1

Ensembl

ENSMUSG00000020805 (Evidence)
NCBI Gene

237831

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020805	Ensembl Gene Model \| MGI Sequence Detail	25234	C57BL/6J	± kb
transcript	ENSMUST00000021161	Ensembl \| MGI Sequence Detail	3329	Not Applicable
polypeptide	ENSMUSP00000021161	Ensembl \| MGI Sequence Detail	572	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014937 Na(+)/citrate cotransporter

(term hierarchy)
InterPro Domains

IPR031312 Sodium/sulphate symporter, conserved site

IPR001898 Solute carrier family 13
GlyGen

Q67BT3 2 sites

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All nucleic 18

cDNA 14

Primer pair 4

Microarray probesets 2

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc13a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109082	Chr11:72157967-72157990 (-)	69 bp
Tssr109081	Chr11:72157447-72157466 (-)	591 bp
Tssr109080	Chr11:72157422-72157437 (-)	618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24