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Macroh2a2 Gene Detail
Summary
  • Symbol
    Macroh2a2
  • Name
    macroH2A.2 histone
  • Synonyms
    H2afy2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037658
    NCBI Gene: 404634
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61574444-61619926 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3037658
 protein coding gene Chr10:61574419-61620383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017288
 protein coding gene Chr10:61107551-61155438 (-)
A/J MGP_AJ_G0017266
 protein coding gene Chr10:59267781-59314817 (-)
AKR/J MGP_AKRJ_G0017226
 protein coding gene Chr10:60813871-60861136 (-)
BALB/cJ MGP_BALBcJ_G0017226
 protein coding gene Chr10:59344457-59389612 (-)
C3H/HeJ MGP_C3HHeJ_G0017049
 protein coding gene Chr10:60717886-60765693 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017684
 protein coding gene Chr10:63307372-63356124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015375
 protein coding gene Chr10:56242159-56288659 (-)
CAST/EiJ MGP_CASTEiJ_G0016620
 protein coding gene Chr10:60735143-60836227 (-)
CBA/J MGP_CBAJ_G0017021
 protein coding gene Chr10:65650329-65710627 (-)
DBA/2J MGP_DBA2J_G0017126
 protein coding gene Chr10:58538708-58584520 (-)
FVB/NJ MGP_FVBNJ_G0017120
 protein coding gene Chr10:57790961-57837895 (-)
LP/J MGP_LPJ_G0017201
 protein coding gene Chr10:61499733-61551522 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017148
 protein coding gene Chr10:67953272-67999560 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017722
 protein coding gene Chr10:60640981-60690712 (-)
PWK/PhJ MGP_PWKPhJ_G0016403
 protein coding gene Chr10:58390853-58438482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016186
 protein coding gene Chr10:60007908-60053836 (-)
WSB/EiJ MGP_WSBEiJ_G0016684
 protein coding gene Chr10:60553790-60600233 (-)



Homology
more
  • Human Ortholog
    MACROH2A2, macroH2A.2 histone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MACROH2A2, macroH2A.2 histone
  • Synonyms
    H2AFY2
  • Links
    NCBI Gene ID: 55506
    neXtProt AC: NX_Q9P0M6
    UniProt: Q9P0M6

  • Chr Location
    10q22.1; chr10:70052544-70112282 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele do not exhibit any developmental or reproductive abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    22
  • cDNA Data
    78
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020086 Ensembl Gene Model | MGI Sequence Detail 45483 C57BL/6J ±  kb
    transcript ENSMUST00000020283 Ensembl | MGI Sequence Detail 2175 Not Applicable  
    polypeptide ENSMUSP00000020283 Ensembl | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 78
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:6325043
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345376 Filipescu D, et al., MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Nat Cell Biol. 2023 Sep;25(9):1332-1345
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory