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Cxcl3 Gene Detail
Summary
  • Symbol
    Cxcl3
  • Name
    C-X-C motif chemokine ligand 3
  • Synonyms
    Dcip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037818
    NCBI Gene: 330122
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90933960-90935952 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3037818
 protein coding gene Chr5:90933960-90937459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029729
 protein coding gene Chr5:91876988-91881626 (+)
A/J MGP_AJ_G0029695
 protein coding gene Chr5:88250982-88254587 (+)
AKR/J MGP_AKRJ_G0029641
 protein coding gene Chr5:91113053-91116536 (+)
BALB/cJ MGP_BALBcJ_G0029705
 protein coding gene Chr5:89151709-89157549 (+)
C3H/HeJ MGP_C3HHeJ_G0029428
 protein coding gene Chr5:91531678-91536001 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030159
 protein coding gene Chr5:95549054-95552551 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027395
 protein coding gene Chr5:83955520-83958995 (+)
CAST/EiJ MGP_CASTEiJ_G0028838
 protein coding gene Chr5:90906018-90909307 (+)
CBA/J MGP_CBAJ_G0029398
 protein coding gene Chr5:98821065-98824560 (+)
DBA/2J MGP_DBA2J_G0029542
 protein coding gene Chr5:88325472-88329085 (+)
FVB/NJ MGP_FVBNJ_G0029501
 protein coding gene Chr5:87187522-87191014 (+)
LP/J MGP_LPJ_G0029630
 protein coding gene Chr5:92255619-92260707 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029530
 protein coding gene Chr5:103805182-103808630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030193
 protein coding gene Chr5:90654261-90658685 (+)
PWK/PhJ MGP_PWKPhJ_G0028557
 protein coding gene Chr5:87384644-87388104 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028392
 protein coding gene Chr5:90073059-90077463 (+)
WSB/EiJ MGP_WSBEiJ_G0028917
 protein coding gene Chr5:91113030-91117592 (+)



Homology
more
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Synonyms
    FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
  • Links
    NCBI Gene ID: 2919
    neXtProt AC: NX_P09341
    UniProt: P09341

  • Chr Location
    4q13.3; chr4:73869393-73871308 (+)  GRCh38
  • Human Ortholog
    CXCL2, C-X-C motif chemokine ligand 2
  • Synonyms
    CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
  • Links
    NCBI Gene ID: 2920
    neXtProt AC: NX_P19875
    UniProt: P19875

  • Chr Location
    4q13.3; chr4:74097040-74099196 (-)  GRCh38
  • Human Ortholog
    CXCL3, C-X-C motif chemokine ligand 3
  • Synonyms
    CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
  • Links
    NCBI Gene ID: 2921
    neXtProt AC: NX_P19876
    UniProt: P19876

  • Chr Location
    4q13.3; chr4:74036589-74038807 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Cxcl3
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 330122 NCBI Gene Model | MGI Sequence Detail 1993 C57BL/6J ±  kb
transcript NM_203320 RefSeq | MGI Sequence Detail 1018 C57BL/6  
polypeptide Q6W5C0 UniProt | EBI | MGI Sequence Detail 100 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:350803 Fang C, et al., TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-kappaB/CXCL3 axis. Int J Biol Sci. 2024;20(6):1992-2007
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory