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Rragb Gene Detail
Summary
  • Symbol
    Rragb
  • Name
    Ras-related GTP binding B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3038613
    NCBI Gene: 245670
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:151922977-151954939 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3038613
 protein coding gene ChrX:151920640-151973188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036193
 protein coding gene ChrX:150945001-150979233 (+)
A/J MGP_AJ_G0036169
 protein coding gene ChrX:150128752-150163629 (+)
AKR/J MGP_AKRJ_G0036095
 protein coding gene ChrX:154957876-154991866 (+)
BALB/cJ MGP_BALBcJ_G0036160
 protein coding gene ChrX:148321247-148353138 (+)
C3H/HeJ MGP_C3HHeJ_G0035868
 protein coding gene ChrX:151194441-151227395 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036685
 protein coding gene ChrX:155314788-155350374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033509
 protein coding gene ChrX:141802638-141836229 (+)
CAST/EiJ MGP_CASTEiJ_G0035159
 protein coding gene ChrX:130514570-130555876 (+)
CBA/J MGP_CBAJ_G0035845
 protein coding gene ChrX:159798419-159838138 (+)
DBA/2J MGP_DBA2J_G0036003
 protein coding gene ChrX:149164133-149196035 (+)
FVB/NJ MGP_FVBNJ_G0035937
 protein coding gene ChrX:148318977-148351085 (+)
LP/J MGP_LPJ_G0036094
 protein coding gene ChrX:152015412-152049658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035973
 protein coding gene ChrX:168059621-168095528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036720
 protein coding gene ChrX:150465499-150501213 (+)
PWK/PhJ MGP_PWKPhJ_G0034853
 protein coding gene ChrX:127471229-127503797 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034678
 protein coding gene ChrX:130934941-130969954 (+)
WSB/EiJ MGP_WSBEiJ_G0035294
 protein coding gene ChrX:148508759-148542213 (+)



Homology
more
  • Human Ortholog
    RRAGB, Ras related GTP binding B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRAGB, Ras related GTP binding B
  • Synonyms
    bA465E19.1, RAGB
  • Links
    NCBI Gene ID: 10325
    neXtProt AC: NX_Q5VZM2
    UniProt: Q5VZM2

  • Chr Location
    Xp11.21; chrX:55717749-55758774 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous or hemizygous for a null allele are viable with no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041658 Ensembl Gene Model | MGI Sequence Detail 31963 C57BL/6J ±  kb
transcript ENSMUST00000039720 Ensembl | MGI Sequence Detail 2258 Not Applicable  
polypeptide ENSMUSP00000039013 Ensembl | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:88987 Sekiguchi T, et al., A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. J Biol Chem. 2004 Feb 27;279(9):8343-50
  • Latest
    J:358941 Zhu X, et al., The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness. Nat Commun. 2024 Nov 23;15(1):10163
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory