Fads6 MGI Mouse Gene Detail - MGI:3039592 - fatty acid desaturase domain family, member 6

Symbol

Fads6
Name

fatty acid desaturase domain family, member 6
Synonyms

BC050213, OTTMUSG00000021749

Feature Type

protein coding gene
IDs

MGI:3039592
NCBI Gene: 328035
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:115170448-115188489 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.84 cM
Mapping Data

2 experiments

SNPs within 2kb

554 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039592	protein coding gene	Chr11:115169453-115188489 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019378	protein coding gene	Chr11:119288377-119310595 (-)
A/J	MGP_AJ_G0019347	protein coding gene	Chr11:114081994-114100418 (-)
AKR/J	MGP_AKRJ_G0019317	protein coding gene	Chr11:117482200-117505654 (-)
BALB/cJ	MGP_BALBcJ_G0019321	protein coding gene	Chr11:114498703-114517027 (-)
C3H/HeJ	MGP_C3HHeJ_G0019127	protein coding gene	Chr11:117836260-117856002 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019771	protein coding gene	Chr11:122928859-122951016 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017394	protein coding gene	Chr11:111123609-111141411 (-)
CAST/EiJ	MGP_CASTEiJ_G0018682	protein coding gene	Chr11:119148603-119169919 (-)
CBA/J	MGP_CBAJ_G0019099	protein coding gene	Chr11:127775960-127794047 (-)
DBA/2J	MGP_DBA2J_G0019210	protein coding gene	Chr11:113521152-113539306 (-)
FVB/NJ	MGP_FVBNJ_G0019202	protein coding gene	Chr11:112992577-113012523 (-)
LP/J	MGP_LPJ_G0019280	protein coding gene	Chr11:119672053-119695240 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019235	protein coding gene	Chr11:126956499-126975537 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019809	protein coding gene	Chr11:118145120-118164940 (-)
PWK/PhJ	MGP_PWKPhJ_G0018446	protein coding gene	Chr11:114798431-114816681 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018239	protein coding gene	Chr11:117886581-117906424 (-)
WSB/EiJ	MGP_WSBEiJ_G0018734	protein coding gene	Chr11:118089574-118108741 (-)

Human Ortholog

FADS6, fatty acid desaturase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FADS6, fatty acid desaturase 6
Synonyms

FP18279
Links

HGNC:30459

NCBI Gene ID: 283985

neXtProt AC: NX_Q8N9I5

UniProt: Q8N9I5
Chr Location

17q25.1; chr17:74874787-74893781 (-) GRCh38

MGI Vertebrate Homology

Fads6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FADS6
Gene Tree

Fads6

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

21

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fads6

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS25626.1

Ensembl

ENSMUSG00000044788 (Evidence)
NCBI Gene

328035

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044788	Ensembl Gene Model \| MGI Sequence Detail	18042	C57BL/6J	± kb
transcript	ENSMUST00000056153	Ensembl \| MGI Sequence Detail	4951	Not Applicable
polypeptide	ENSMUSP00000058783	Ensembl \| MGI Sequence Detail	342	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007320 fatty acid desaturase 6

(term hierarchy)
EC

1.14.19.-
InterPro Domains

IPR012171 Fatty acid desaturase

IPR005804 Fatty acid desaturase domain

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All nucleic 21

cDNA 21

Microarray probesets 3

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MGI:3707356

Summaries

All 35

Gene Ontology 4

Phenotypes 10
Earliest

J:82022 Kikkawa Y, et al., Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet. 2003 Mar 1;12(5):453-61
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fads6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111747	Chr11:115188444-115188457 (-)	38 bp
Tssr111746	Chr11:115188347-115188406 (-)	112 bp
Tssr111745	Chr11:115188336-115188345 (-)	148 bp
Tssr3731	Chr11:115188327-115188334 (-)	158 bp
Tssr111744	Chr11:115188322-115188327 (-)	164 bp
Tssr111743	Chr11:115182360-115182384 (-)	6,117 bp
Tssr111742	Chr11:115176271-115176295 (-)	12,206 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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