Tox3 MGI Mouse Gene Detail - MGI:3039593 - TOX high mobility group box family member 3

Symbol

Tox3
Name

TOX high mobility group box family member 3
Synonyms

500-9, C230068E13, CAGF9, Tnrc9

Feature Type

protein coding gene
IDs

MGI:3039593
NCBI Gene: 244579
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:90973668-91074971 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 43.96 cM
Mapping Data

3 experiments

SNPs within 2kb

2524 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039593	protein coding gene	Chr8:90973665-91075746 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033926	protein coding gene	Chr8:91422445-91525123 (-)
A/J	MGP_AJ_G0033909	protein coding gene	Chr8:87831491-87936769 (-)
AKR/J	MGP_AKRJ_G0033835	protein coding gene	Chr8:90325335-90426173 (-)
BALB/cJ	MGP_BALBcJ_G0033901	protein coding gene	Chr8:87974970-88075703 (-)
C3H/HeJ	MGP_C3HHeJ_G0033611	protein coding gene	Chr8:90990926-91096814 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034422	protein coding gene	Chr8:94840684-94943991 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031363	protein coding gene	Chr8:81796974-81896571 (-)
CAST/EiJ	MGP_CASTEiJ_G0032943	protein coding gene	Chr8:90482039-90589498 (-)
CBA/J	MGP_CBAJ_G0033587	protein coding gene	Chr8:98034934-98140129 (-)
DBA/2J	MGP_DBA2J_G0033741	protein coding gene	Chr8:87395212-87494990 (-)
FVB/NJ	MGP_FVBNJ_G0033688	protein coding gene	Chr8:86344164-86444945 (-)
LP/J	MGP_LPJ_G0033833	protein coding gene	Chr8:91534413-91641725 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033731	protein coding gene	Chr8:100446997-100551750 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034440	protein coding gene	Chr8:90409676-90515152 (-)
PWK/PhJ	MGP_PWKPhJ_G0032645	protein coding gene	Chr8:86688746-86792620 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032482	protein coding gene	Chr8:89258771-89366877 (-)
WSB/EiJ	MGP_WSBEiJ_G0033055	protein coding gene	Chr8:90867423-90974617 (-)

Human Ortholog

TOX3, TOX high mobility group box family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOX3, TOX high mobility group box family member 3
Synonyms

CAGF9, TNRC9
Links

HGNC:11972

NCBI Gene ID: 27324

neXtProt AC: NX_O15405

UniProt: O15405
Chr Location

16q12.1; chr16:52436416-52547802 (-) GRCh38

MGI Vertebrate Homology

Tox3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TOX3
Gene Tree

Tox3

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1108
Tissues

117
cDNA Data

25
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tox3

ZFIN tox3

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All Sequences

45
RefSeq

10
UniProt

3
CCDS

CCDS22516.1

Ensembl

ENSMUSG00000043668 (Evidence)
NCBI Gene

244579

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043668	Ensembl Gene Model \| MGI Sequence Detail	101304	C57BL/6J	± kb
transcript	ENSMUST00000109621	Ensembl \| MGI Sequence Detail	3356	Not Applicable
polypeptide	ENSMUSP00000105250	Ensembl \| MGI Sequence Detail	575	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031301 TOX high mobility group box family member 3

(term hierarchy)
InterPro Domains

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR051365 TOX high mobility group box domain-containing protein

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All nucleic 30

cDNA 26

Primer pair 3

Other 1

Microarray probesets 1

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MGI:3573728

Summaries

All 55

Developmental Gene Expression 17

Gene Ontology 7

Phenotypes 13
Earliest

J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tox3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82398	Chr8:91074971-91075014 (-)	-22 bp
Tssr82397	Chr8:91074906-91074930 (-)	53 bp
Tssr2640	Chr8:91074754-91074788 (-)	200 bp
Tssr82396	Chr8:91073822-91073829 (-)	1,145 bp
Tssr82395	Chr8:91052554-91052566 (-)	22,411 bp
Tssr82394	Chr8:91027990-91027994 (-)	46,979 bp
Tssr82393	Chr8:91025032-91025037 (-)	49,936 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24