Timd6 MGI Mouse Gene Detail - MGI:3039605 - T cell immunoglobulin and mucin domain containing 6

Symbol

Timd6
Name

T cell immunoglobulin and mucin domain containing 6
Synonyms

BC053393

Feature Type

protein coding gene
IDs

MGI:3039605
NCBI Gene: 407814
Alliance

gene page

Sequence Map

Chr11:46462363-46480059 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 28.00 cM
Mapping Data

1 experiment

SNPs within 2kb

849 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039605	protein coding gene	Chr11:46462340-46480059 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018197	protein coding gene	Chr11:45495435-45514402 (+)
A/J	MGP_AJ_G0018169	protein coding gene	Chr11:43734752-43752318 (+)
AKR/J	MGP_AKRJ_G0018135	protein coding gene	Chr11:45031621-45048743 (+)
BALB/cJ	MGP_BALBcJ_G0018138	protein coding gene	Chr11:43892978-43910512 (+)
C3H/HeJ	MGP_C3HHeJ_G0017952	protein coding gene	Chr11:45040015-45057344 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018592	protein coding gene	Chr11:46842050-46859357 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016247	protein coding gene	Chr11:41711852-41728185 (+)
CAST/EiJ	MGP_CASTEiJ_G0017515	protein coding gene	Chr11:45170455-45188645 (+)
CBA/J	MGP_CBAJ_G0017924	protein coding gene	Chr11:49033167-49050342 (+)
DBA/2J	MGP_DBA2J_G0018034	protein coding gene	Chr11:43483046-43500587 (+)
FVB/NJ	MGP_FVBNJ_G0018028	protein coding gene	Chr11:43156228-43188016 (+)
LP/J	MGP_LPJ_G0018106	protein coding gene	Chr11:45755130-45774531 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018052	protein coding gene	Chr11:50566290-50588695 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018631	protein coding gene	Chr11:45165743-45189110 (+)
PWK/PhJ	MGP_PWKPhJ_G0017295	protein coding gene	Chr11:43588848-43608458 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017088	protein coding gene	Chr11:44993264-45011698 (+)
WSB/EiJ	MGP_WSBEiJ_G0017565	protein coding gene	Chr11:44860580-44881276 (+)

Human Ortholog

HAVCR1, hepatitis A virus cellular receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HAVCR1, hepatitis A virus cellular receptor 1
Synonyms

CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1
Links

HGNC:17866

NCBI Gene ID: 26762

neXtProt AC: NX_Q96D42

UniProt: Q96D42
Chr Location

5q33.3; chr5:157026742-157069407 (-) GRCh38

MGI Vertebrate Homology

Timd6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HAVCR1
Gene Tree

Timd6

Diseases

1 with human HAVCR1 associations

				Human Disease	Mouse Models
				atopic dermatitis IDs atopic dermatitis DOID:3310 EFO:0000274 ICD10CM:L20 MESH:D003876 OMIM:603165 OMIM:PS603165 UMLS_CUI:C0011615

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Timd6
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

47
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS24580.1

Ensembl

ENSMUSG00000046974 (Evidence)
NCBI Gene

407814

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046974	Ensembl Gene Model \| MGI Sequence Detail	17697	C57BL/6J	± kb
transcript	ENSMUST00000050937	Ensembl \| MGI Sequence Detail	2020	Not Applicable
polypeptide	ENSMUSP00000050057	Ensembl \| MGI Sequence Detail	192	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR052331 T-cell immunoglobulin and mucin domain-containing protein

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All nucleic 47

cDNA 47

Microarray probesets 3

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MGI:7516779

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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