Vtcn1 MGI Mouse Gene Detail - MGI:3039619 - V-set domain containing T cell activation inhibitor 1

Symbol

Vtcn1
Name

V-set domain containing T cell activation inhibitor 1
Synonyms

B7-H4, B7x

Feature Type

protein coding gene
IDs

MGI:3039619
NCBI Gene: 242122
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:100732775-100804238 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.78 cM
Mapping Data

1 experiment

SNPs within 2kb

2299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039619	protein coding gene	Chr3:100732775-100805555 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027669	protein coding gene	Chr3:101954227-102030786 (+)
A/J	MGP_AJ_G0027628	protein coding gene	Chr3:98745816-98818786 (+)
AKR/J	MGP_AKRJ_G0027594	protein coding gene	Chr3:101165242-101241409 (+)
BALB/cJ	MGP_BALBcJ_G0027641	protein coding gene	Chr3:98504478-98579132 (+)
C3H/HeJ	MGP_C3HHeJ_G0027370	protein coding gene	Chr3:101455279-101535767 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028084	protein coding gene	Chr3:105701320-105776398 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025425	protein coding gene	Chr3:94942784-95014775 (+)
CAST/EiJ	MGP_CASTEiJ_G0026826	protein coding gene	Chr3:100549358-100631177 (+)
CBA/J	MGP_CBAJ_G0027345	protein coding gene	Chr3:109331860-109420579 (+)
DBA/2J	MGP_DBA2J_G0027488	protein coding gene	Chr3:97985824-98057446 (+)
FVB/NJ	MGP_FVBNJ_G0027456	protein coding gene	Chr3:95917109-95990585 (+)
LP/J	MGP_LPJ_G0027595	protein coding gene	Chr3:103318939-103396904 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027486	protein coding gene	Chr3:115567661-115647321 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028139	protein coding gene	Chr3:100651820-100728249 (+)
PWK/PhJ	MGP_PWKPhJ_G0026553	protein coding gene	Chr3:97737611-97811891 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026375	protein coding gene	Chr3:98748492-98826356 (+)
WSB/EiJ	MGP_WSBEiJ_G0026906	protein coding gene	Chr3:101215478-101289007 (+)

Human Ortholog

VTCN1, V-set domain containing T cell activation inhibitor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VTCN1, V-set domain containing T cell activation inhibitor 1
Synonyms

B7-H4, B7H4, B7h.5, B7S1, B7X, PRO1291, VCTN1
Links

HGNC:28873

NCBI Gene ID: 79679

neXtProt AC: NX_Q7Z7D3

UniProt: Q7Z7D3
Chr Location

1p13.1-p12; chr1:117143587-117210960 (-) GRCh38

MGI Vertebrate Homology

Vtcn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VTCN1
Gene Tree

Vtcn1

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 3 alleles in 4 genetic backgrounds
9 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

10
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

2 involving Vtcn1
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for this mutation display stronger Th1 responses upon parasitic infection by L. major including reduced footpad swelling and lower parasite burden compared to controls. Responses to other Th1-driven immune responses are normal.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

15
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vtcn1

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS17677.1

Ensembl

ENSMUSG00000051076 (Evidence)
NCBI Gene

242122

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051076	Ensembl Gene Model \| MGI Sequence Detail	71464	C57BL/6J	± kb
transcript	ENSMUST00000054791	Ensembl \| MGI Sequence Detail	2622	Not Applicable
polypeptide	ENSMUSP00000057721	Ensembl \| MGI Sequence Detail	283	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017357 V-set domain-containing T-cell activation inhibitor 1

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR050504 Immunoglobulin superfamily BTN/MOG domain-containing protein

IPR013106 Immunoglobulin V-set domain
GlyGen

Q7TSP5 1 site

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 2

Summaries

All 56

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 25
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:352035 Yu J, et al., Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell. 2024 Jun 28;

TSS for Vtcn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30883	Chr3:100732768-100732783 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24