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Rpl23a Gene Detail
Summary
  • Symbol
    Rpl23a
  • Name
    ribosomal protein L23A
  • Synonyms
    MDA20
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040672
    NCBI Gene: 268449
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78071761-78074410 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040672
 protein coding gene Chr11:78071758-78074410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018767
 protein coding gene Chr11:79162562-79165214 (-)
A/J MGP_AJ_G0018733
 protein coding gene Chr11:76139719-76142371 (-)
AKR/J MGP_AKRJ_G0018703
 protein coding gene Chr11:78444830-78447482 (-)
BALB/cJ MGP_BALBcJ_G0018707
 protein coding gene Chr11:76548937-76551589 (-)
C3H/HeJ MGP_C3HHeJ_G0018520
 protein coding gene Chr11:78485915-78488567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019158
 protein coding gene Chr11:81634180-81636832 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016793
 protein coding gene Chr11:73113707-73116387 (-)
CAST/EiJ MGP_CASTEiJ_G0018074
 protein coding gene Chr11:78923045-78925703 (-)
CBA/J MGP_CBAJ_G0018490
 protein coding gene Chr11:85196098-85198750 (-)
DBA/2J MGP_DBA2J_G0018599
 protein coding gene Chr11:75721865-75724517 (-)
FVB/NJ MGP_FVBNJ_G0018589
 protein coding gene Chr11:75309715-75312367 (-)
LP/J MGP_LPJ_G0018670
 protein coding gene Chr11:79698302-79700954 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018615
 protein coding gene Chr11:85618275-85620927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019198
 protein coding gene Chr11:78687674-78690326 (-)
PWK/PhJ MGP_PWKPhJ_G0017845
 protein coding gene Chr11:76503561-76506831 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017636
 protein coding gene Chr11:78295416-78299014 (-)
WSB/EiJ MGP_WSBEiJ_G0018127
 protein coding gene Chr11:78501241-78503891 (-)



Homology
more
  • Human Ortholog
    RPL23A, ribosomal protein L23a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL23A, ribosomal protein L23a
  • Synonyms
    L23A, MDA20, uL23
  • Links
    NCBI Gene ID: 6147
    neXtProt AC: NX_P62750
    UniProt: P62750

  • Chr Location
    17q11.2; chr17:28719985-28724359 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    9
  • Targeted
    1
  • Genomic Mutations
    2 involving Rpl23a
  • Find Mice (IMSR)
    7 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 268449 NCBI Gene Model | MGI Sequence Detail 2650 C57BL/6J ±  kb
transcript NM_207523 RefSeq | MGI Sequence Detail 560 C57BL/6  
polypeptide P62751 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014204 eukaryotic-type large ribosomal subunit protein uL23
    (term hierarchy)
  • PDB
    6SWA, 7CPU, 7CPV, 7LS1, 7LS2
  • InterPro Domains
    IPR019985 Large ribosomal subunit protein uL23
    IPR001014 Large ribosomal subunit protein uL23, conserved site
    IPR013025 Large ribosomal subunit protein uL23-like
    IPR005633 Large ribosomal subunit protein uL23, N-terminal
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR012678 Ribosomal protein uL23/eL15/eS24 core domain superfamily
  • GlyGen
    P62751 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 13
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory