Wdcp MGI Mouse Gene Detail - MGI:3040699 - WD repeat and coiled coil containing

Symbol

Wdcp
Name

WD repeat and coiled coil containing
Synonyms

BC068281

Feature Type

protein coding gene
IDs

MGI:3040699
NCBI Gene: 238037
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:4893303-4910043 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 2.10 cM
Mapping Data

1 experiment

SNPs within 2kb

655 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3040699	protein coding gene	Chr12:4892384-4910049 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019576	protein coding gene	Chr12:1755615-1774305 (+)
A/J	MGP_AJ_G0019543	protein coding gene	Chr12:1721164-1734711 (+)
AKR/J	MGP_AKRJ_G0019513	protein coding gene	Chr12:1913607-1929188 (+)
BALB/cJ	MGP_BALBcJ_G0019518	protein coding gene	Chr12:1760373-1774264 (+)
C3H/HeJ	MGP_C3HHeJ_G0019324	protein coding gene	Chr12:1688946-1707661 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019967	protein coding gene	Chr12:1800198-1820090 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017592	protein coding gene	Chr12:1707637-1721190 (+)
CAST/EiJ	MGP_CASTEiJ_G0018879	protein coding gene	Chr12:1776641-1790480 (+)
CBA/J	MGP_CBAJ_G0019295	protein coding gene	Chr12:2110873-2126669 (+)
DBA/2J	MGP_DBA2J_G0019408	protein coding gene	Chr12:1656140-1670163 (+)
FVB/NJ	MGP_FVBNJ_G0019399	protein coding gene	Chr12:1664596-1682649 (+)
LP/J	MGP_LPJ_G0019479	protein coding gene	Chr12:1760523-1775566 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019432	protein coding gene	Chr12:1856412-1871335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020006	protein coding gene	Chr12:1730319-1750641 (+)
PWK/PhJ	MGP_PWKPhJ_G0018645	protein coding gene	Chr12:1714358-1728939 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018436	protein coding gene	Chr12:1761794-1776340 (+)
WSB/EiJ	MGP_WSBEiJ_G0018930	protein coding gene	Chr12:1722997-1737834 (+)

Human Ortholog

WDCP, WD repeat and coiled coil containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDCP, WD repeat and coiled coil containing
Synonyms

C2orf44, MMAP, PP384
Links

HGNC:26157

NCBI Gene ID: 80304

neXtProt AC: NX_Q9H6R7

UniProt: Q9H6R7
Chr Location

2p23.3; chr2:24029347-24049575 (-) GRCh38

MGI Vertebrate Homology

Wdcp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDCP
Gene Tree

Wdcp

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

1
Gene trapped

28
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdcp

ZFIN wdcp

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All Sequences

58
RefSeq

16
UniProt

3
CCDS

CCDS25793.1, CCDS49019.1

Ensembl

ENSMUSG00000051721 (Evidence)
NCBI Gene

238037

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051721	Ensembl Gene Model \| MGI Sequence Detail	16741	C57BL/6J	± kb
transcript	ENSMUST00000223551	Ensembl \| MGI Sequence Detail	4317	Not Applicable
polypeptide	ENSMUSP00000152571	Ensembl \| MGI Sequence Detail	710	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060082 WD repeat and coiled-coil-containing protein

(term hierarchy)
InterPro Domains

IPR028041 WD repeat and coiled-coil-containing protein family

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All nucleic 16

cDNA 16

Microarray probesets 3

Summaries

All 28

Gene Ontology 2

Phenotypes 8
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Wdcp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112589	Chr12:4893316-4893419 (+)	65 bp
Tssr3769	Chr12:4900722-4900726 (+)	7,421 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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