Zscan10 MGI Mouse Gene Detail - MGI:3040700 - zinc finger and SCAN domain containing 10

Symbol

Zscan10
Name

zinc finger and SCAN domain containing 10
Synonyms

Zfp206, Zscan10

Feature Type

protein coding gene
IDs

MGI:3040700
NCBI Gene: 332221
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:23819830-23829993 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 11.79 cM, cytoband A3
Mapping Data

1 experiment

SNPs within 2kb

383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3040700	protein coding gene	Chr17:23819800-23829993 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023258	protein coding gene	Chr17:22501843-22514470 (+)
A/J	MGP_AJ_G0023218	protein coding gene	Chr17:21862500-21872618 (+)
AKR/J	MGP_AKRJ_G0023188	protein coding gene	Chr17:21932928-21945891 (+)
BALB/cJ	MGP_BALBcJ_G0023223	protein coding gene	Chr17:22076458-22086732 (+)
C3H/HeJ	MGP_C3HHeJ_G0022983	protein coding gene	Chr17:22294839-22308777 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023666	protein coding gene	Chr17:23486036-23500897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021147	protein coding gene	Chr17:19435722-19446392 (+)
CAST/EiJ	MGP_CASTEiJ_G0022489	protein coding gene	Chr17:22126274-22138376 (+)
CBA/J	MGP_CBAJ_G0022959	protein coding gene	Chr17:24274077-24289817 (+)
DBA/2J	MGP_DBA2J_G0023091	protein coding gene	Chr17:21491468-21501846 (+)
FVB/NJ	MGP_FVBNJ_G0023058	protein coding gene	Chr17:21215739-21225581 (+)
LP/J	MGP_LPJ_G0023165	protein coding gene	Chr17:22762214-22772391 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023077	protein coding gene	Chr17:24060238-24072198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023705	protein coding gene	Chr17:22226142-22237814 (+)
PWK/PhJ	MGP_PWKPhJ_G0022237	protein coding gene	Chr17:20278506-20289031 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022057	protein coding gene	Chr17:20250564-20262099 (+)
WSB/EiJ	MGP_WSBEiJ_G0022552	protein coding gene	Chr17:22281599-22293294 (+)

Human Ortholog

ZSCAN10, zinc finger and SCAN domain containing 10

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZSCAN10, zinc finger and SCAN domain containing 10
Synonyms

OFNS, ZFP206, ZNF206
Links

HGNC:12997

NCBI Gene ID: 84891

neXtProt AC: NX_Q96SZ4

UniProt: Q96SZ4
Chr Location

16p13.3

MGI Vertebrate Homology

Zscan10 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZSCAN10
Gene Tree

Zscan10

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Phenotype Summary

44 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

304
Endonuclease-mediated

1
Gene trapped

298
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

200 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit a pleiotropic phenotype including reduced weight, mild hypoplasia in the spleen, heart and long bones, eye malformations including microphthalmia, altered platelet counts, an activated immune status, and behavioral alterations.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

950
Tissues

188
cDNA Data

31
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

82
RefSeq

10
UniProt

10
CCDS

CCDS28451.1, CCDS70766.1, CCDS79510.1

Ensembl

ENSMUSG00000023902 (Evidence)
NCBI Gene

332221

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023902	Ensembl Gene Model \| MGI Sequence Detail	10164	C57BL/6J	± kb
transcript	ENSMUST00000095595	Ensembl \| MGI Sequence Detail	2698	Not Applicable
polypeptide	ENSMUSP00000093255	Ensembl \| MGI Sequence Detail	782	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000018221 zinc finger and SCAN domain-containing protein 10

(term hierarchy)
PDB

4E6S
InterPro Domains

IPR003309 SCAN domain

IPR050916 SCAN domain and C2H2-type zinc finger

IPR038269 SCAN domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 38

cDNA 31

Primer pair 5

Other 2

Microarray probesets 1

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 15
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:358506 Laugwitz L, et al., ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations. Brain. 2024 Feb 22;

TSS for Zscan10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142924	Chr17:23818250-23818306 (+)	-1,552 bp
Tssr142925	Chr17:23819779-23819794 (+)	-43 bp
Tssr142926	Chr17:23819806-23819813 (+)	-20 bp
Tssr142927	Chr17:23819818-23819857 (+)	8 bp
Tssr142928	Chr17:23819861-23819903 (+)	52 bp
Tssr142929	Chr17:23820449-23820488 (+)	639 bp
Tssr142930	Chr17:23823606-23823632 (+)	3,789 bp
Tssr142931	Chr17:23823645-23823657 (+)	3,821 bp
Tssr142932	Chr17:23823664-23823680 (+)	3,842 bp
Tssr142933	Chr17:23823683-23823699 (+)	3,861 bp
Tssr142934	Chr17:23829441-23829463 (+)	9,622 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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