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Clec12a Gene Detail
Summary
  • Symbol
    Clec12a
  • Name
    C-type lectin domain family 12, member a
  • Synonyms
    Micl
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040968
    NCBI Gene: 232413
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129327207-129342266 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040968
 protein coding gene Chr6:129319654-129342266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031344
 protein coding gene Chr6:133006132-133030280 (+)
A/J MGP_AJ_G0031315
 protein coding gene Chr6:127914577-127938600 (+)
AKR/J MGP_AKRJ_G0031243
 protein coding gene Chr6:131412816-131435389 (+)
BALB/cJ MGP_BALBcJ_G0031322
 protein coding gene Chr6:127562563-127586738 (+)
C3H/HeJ MGP_C3HHeJ_G0031046
 protein coding gene Chr6:131602382-131629779 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031781
 protein coding gene Chr6:136500198-136526696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028927
 protein coding gene Chr6:126247457-126262905 (+)
CAST/EiJ MGP_CASTEiJ_G0030424
 protein coding gene Chr6:131836838-131855149 (+)
CBA/J MGP_CBAJ_G0031006
 protein coding gene Chr6:141865210-141893973 (+)
DBA/2J MGP_DBA2J_G0031163
 protein coding gene Chr6:126868061-126891248 (+)
FVB/NJ MGP_FVBNJ_G0031113
 protein coding gene Chr6:125751415-125774556 (+)
LP/J MGP_LPJ_G0031243
 protein coding gene Chr6:133220886-133247451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031151
 protein coding gene Chr6:145716244-145743309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031814
 protein coding gene Chr6:131478517-131501968 (+)
PWK/PhJ MGP_PWKPhJ_G0030142
 protein coding gene Chr6:125148528-125171993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029971
 protein coding gene Chr6:129494357-129517396 (+)
WSB/EiJ MGP_WSBEiJ_G0030512
 protein coding gene Chr6:131895054-131921439 (+)



Homology
more
  • Human Ortholog
    CLEC12A, C-type lectin domain family 12 member A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC12A, C-type lectin domain family 12 member A
  • Synonyms
    CD371, CLL-1, CLL1, DCAL-2, MICL
  • Links
    NCBI Gene ID: 160364
    neXtProt AC: NX_Q5QGZ9
    UniProt: Q5QGZ9

  • Chr Location
    12p13.31-p13.2; chr12:9951268-10006150 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperinflammatory responses following challenge with uric acid crystals (monosodium urate) or necrotic cells and after radiation-induced thymocyte killing. Homozygotes for a different null allele show increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    5
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232413 NCBI Gene Model | MGI Sequence Detail 15060 C57BL/6J ±  kb
transcript NM_177686 RefSeq | MGI Sequence Detail 2222 C57BL/6  
polypeptide Q504P2 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005559 C-type lectin domain family 12 member A
    (term hierarchy)
  • InterPro Domains
    IPR042916 C-type lectin domain family 12 member A/B
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
  • GlyGen
    Q504P2 4 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 13
    Phenotypes 12
  • Earliest
    J:89520 Marshall AS, et al., Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem. 2004 Apr 9;279(15):14792-802
  • Latest
    J:355680 Malamud M, et al., Recognition and control of neutrophil extracellular trap formation by MICL. Nature. 2024 Sep;633(8029):442-450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory