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Adgrd1 Gene Detail
Summary
  • Symbol
    Adgrd1
  • Name
    adhesion G protein-coupled receptor D1
  • Synonyms
    E230012M21Rik, Gpr133
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041203
    NCBI Gene: 243277
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129173814-129281663 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 67.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041203
 protein coding gene Chr5:129173741-129281663 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030124
 protein coding gene Chr5:133160665-133287640 (+)
A/J MGP_AJ_G0030091
 protein coding gene Chr5:127564744-127687202 (+)
AKR/J MGP_AKRJ_G0030025
 protein coding gene Chr5:131714001-131834268 (+)
BALB/cJ MGP_BALBcJ_G0030101
 protein coding gene Chr5:128909217-129029783 (+)
C3H/HeJ MGP_C3HHeJ_G0029818
 protein coding gene Chr5:132283806-132397283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030554
 protein coding gene Chr5:138272192-138392741 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027779
 protein coding gene Chr5:121964455-122083044 (+)
CAST/EiJ MGP_CASTEiJ_G0029227
 protein coding gene Chr5:131553751-131679125 (+)
CBA/J MGP_CBAJ_G0029788
 protein coding gene Chr5:143634495-143760201 (+)
DBA/2J MGP_DBA2J_G0029938
 protein coding gene Chr5:127549901-127658460 (+)
FVB/NJ MGP_FVBNJ_G0029894
 protein coding gene Chr5:126610351-126731865 (+)
LP/J MGP_LPJ_G0030027
 protein coding gene Chr5:133668556-133797415 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029925
 protein coding gene Chr5:147023047-147154673 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030595
 protein coding gene Chr5:131387876-131513962 (+)
PWK/PhJ MGP_PWKPhJ_G0028941
 protein coding gene Chr5:126456462-126578273 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028778
 protein coding gene Chr5:128958129-129089174 (+)
WSB/EiJ MGP_WSBEiJ_G0029301
 protein coding gene Chr5:132053209-132177169 (+)



Homology
more
  • Human Ortholog
    ADGRD1, adhesion G protein-coupled receptor D1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRD1, adhesion G protein-coupled receptor D1
  • Synonyms
    GPR133, PGR25
  • Links
    NCBI Gene ID: 283383
    neXtProt AC: NX_Q6QNK2
    UniProt: Q6QNK2

  • Chr Location
    12q24.33; chr12:130953907-131141469 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit female infertility associated with failure to overcome the tubal-locking following fertilization and reduced oviductal luminal fluid production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    20
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044017 Ensembl Gene Model | MGI Sequence Detail 107850 C57BL/6J ±  kb
    transcript ENSMUST00000056617 Ensembl | MGI Sequence Detail 5163 Not Applicable  
    polypeptide ENSMUSP00000060307 Ensembl | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR046338 GAIN domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR001759 Pentraxin-related
    • GlyGen
      Q80T32 14 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory