Sema3g MGI Mouse Gene Detail - MGI:3041242 - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

Symbol

Sema3g
Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

Feature Type

protein coding gene
IDs

MGI:3041242
NCBI Gene: 218877
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:30939830-30952309 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.09 cM
Mapping Data

1 experiment

SNPs within 2kb

454 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3041242	protein coding gene	Chr14:30939817-30952309 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021123	protein coding gene	Chr14:24392844-24406398 (+)
A/J	MGP_AJ_G0021071	protein coding gene	Chr14:23471545-23483894 (+)
AKR/J	MGP_AKRJ_G0021048	protein coding gene	Chr14:24595525-24607888 (+)
BALB/cJ	MGP_BALBcJ_G0021075	protein coding gene	Chr14:23593811-23608598 (+)
C3H/HeJ	MGP_C3HHeJ_G0020858	protein coding gene	Chr14:24464926-24477275 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021507	protein coding gene	Chr14:25360963-25374139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019070	protein coding gene	Chr14:23536602-23548914 (+)
CAST/EiJ	MGP_CASTEiJ_G0020383	protein coding gene	Chr14:24228914-24241297 (+)
CBA/J	MGP_CBAJ_G0020825	protein coding gene	Chr14:26334276-26346615 (+)
DBA/2J	MGP_DBA2J_G0020947	protein coding gene	Chr14:23501417-23514011 (+)
FVB/NJ	MGP_FVBNJ_G0020931	protein coding gene	Chr14:23464121-23476432 (+)
LP/J	MGP_LPJ_G0021016	protein coding gene	Chr14:24718682-24731477 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020957	protein coding gene	Chr14:25598083-25610450 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021540	protein coding gene	Chr14:24356833-24369210 (+)
PWK/PhJ	MGP_PWKPhJ_G0020131	protein coding gene	Chr14:22958759-22971855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019955	protein coding gene	Chr14:23952526-23966364 (+)
WSB/EiJ	MGP_WSBEiJ_G0020438	protein coding gene	Chr14:24419456-24431834 (+)

Human Ortholog

SEMA3G, semaphorin 3G

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEMA3G, semaphorin 3G
Synonyms

sem2
Links

HGNC:30400

NCBI Gene ID: 56920

neXtProt AC: NX_Q9NS98

UniProt: Q9NS98
Chr Location

3p21.1; chr3:52433035-52445103 (-) GRCh38

MGI Vertebrate Homology

Sema3g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEMA3G
Gene Tree

Sema3g

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased lymphatic branching complexity with decreased lymphatic width.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

13
cDNA Data

20
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS26908.1

Ensembl

ENSMUSG00000021904 (Evidence)
NCBI Gene

218877

			Length	Strain/Species	Flank
genomic	218877	NCBI Gene Model \| MGI Sequence Detail	12480	C57BL/6J	± kb
transcript	NM_001025379	RefSeq \| MGI Sequence Detail	3686	C57BL/6
polypeptide	Q4LFA9	UniProt \| EBI \| MGI Sequence Detail	780	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014621 semaphorin-3G

(term hierarchy)
InterPro Domains

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR016201 PSI domain

IPR001627 Sema domain

IPR036352 Sema domain superfamily

IPR027231 Semaphorin

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q4LFA9 4 sites, 3 N-linked glycans (4 sites)

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All nucleic 23

cDNA 20

Other 3

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 14

Gene Ontology 4

Phenotypes 7
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:330969 Martins LF, et al., Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. Neuron. 2022 Oct 7;

TSS for Sema3g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124936	Chr14:30939807-30939823 (+)	-15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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