Tgm6 MGI Mouse Gene Detail - MGI:3044321

Symbol

Tgm6
Name

transglutaminase 6
Synonyms

TGM3L

Feature Type

protein coding gene
IDs

MGI:3044321
NCBI Gene: 241636
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:129954336-129996152 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.19 cM
Mapping Data

1 experiment

SNPs within 2kb

1550 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3044321	protein coding gene	Chr2:129954336-129996153 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026494	protein coding gene	Chr2:133536573-133593716 (+)
A/J	MGP_AJ_G0026458	protein coding gene	Chr2:128148756-128190499 (+)
AKR/J	MGP_AKRJ_G0026433	protein coding gene	Chr2:131813911-131857644 (+)
BALB/cJ	MGP_BALBcJ_G0026470	protein coding gene	Chr2:128500814-128543766 (+)
C3H/HeJ	MGP_C3HHeJ_G0026213	protein coding gene	Chr2:132271583-132313307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026915	protein coding gene	Chr2:137690642-137734947 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024292	protein coding gene	Chr2:122895030-122935963 (+)
CAST/EiJ	MGP_CASTEiJ_G0025674	protein coding gene	Chr2:132514410-132564298 (+)
CBA/J	MGP_CBAJ_G0026193	protein coding gene	Chr2:142783079-142833703 (+)
DBA/2J	MGP_DBA2J_G0026327	protein coding gene	Chr2:127536827-127578673 (+)
FVB/NJ	MGP_FVBNJ_G0026291	protein coding gene	Chr2:126157478-126199096 (+)
LP/J	MGP_LPJ_G0026432	protein coding gene	Chr2:133793155-133836353 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026311	protein coding gene	Chr2:146646136-146693895 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026970	protein coding gene	Chr2:131790859-131836284 (+)
PWK/PhJ	MGP_PWKPhJ_G0025410	protein coding gene	Chr2:127087477-127131381 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025212	protein coding gene	Chr2:130917601-130960070 (+)
WSB/EiJ	MGP_WSBEiJ_G0025748	protein coding gene	Chr2:132718102-132764800 (+)

Human Ortholog

TGM6, transglutaminase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TGM6, transglutaminase 6
Synonyms

dJ734P14.3, SCA35, TG6, TGM3L, TGY
Links

HGNC:16255

NCBI Gene ID: 343641

neXtProt AC: NX_O95932

UniProt: O95932
Chr Location

20p13; chr20:2380901-2432753 (+) GRCh38

MGI Vertebrate Homology

Tgm6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TGM6
Protein SuperFamily

TGM_EBP42
Gene Tree

Tgm6

Diseases

1 with human TGM6 associations

				Human Disease	Mouse Models
				spinocerebellar ataxia type 35 IDs spinocerebellar ataxia type 35 DOID:0050982 OMIM:613908

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tgm6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

5
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tgm6

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All Sequences

44
RefSeq

8
UniProt

4
CCDS

CCDS16734.1

Ensembl

ENSMUSG00000027403 (Evidence)
NCBI Gene

241636

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027403	Ensembl Gene Model \| MGI Sequence Detail	41817	C57BL/6J	± kb
transcript	ENSMUST00000028888	Ensembl \| MGI Sequence Detail	3327	Not Applicable
polypeptide	ENSMUSP00000028888	Ensembl \| MGI Sequence Detail	706	Not Applicable

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UniProt

4 Sequences
EC

2.3.2.13
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR038765 Papain-like cysteine peptidase superfamily

IPR023608 Protein-glutamine gamma-glutamyltransferase, animal

IPR050779 Protein-glutamine gamma-glutamyltransferases

IPR013808 Transglutaminase, active site

IPR008958 Transglutaminase, C-terminal

IPR036238 Transglutaminase, C-terminal domain superfamily

IPR002931 Transglutaminase-like

IPR036985 Transglutaminase-like superfamily

IPR001102 Transglutaminase, N-terminal

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tgm6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20197	Chr2:129965195-129965213 (+)	10,868 bp
Tssr20198	Chr2:129965230-129965234 (+)	10,896 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24