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Begain Gene Detail
Summary
  • Symbol
    Begain
  • Name
    brain-enriched guanylate kinase-associated
  • Synonyms
    LOC380785
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044626
    NCBI Gene: 380785
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108998113-109034143 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    784 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044626
 protein coding gene Chr12:108998107-109034168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020113
 protein coding gene Chr12:111208206-111249152 (-)
A/J MGP_AJ_G0020067
 protein coding gene Chr12:106974559-107011167 (-)
AKR/J MGP_AKRJ_G0020043
 protein coding gene Chr12:110094134-110134927 (-)
BALB/cJ MGP_BALBcJ_G0020053
 protein coding gene Chr12:107391170-107412714 (-)
C3H/HeJ MGP_C3HHeJ_G0019855
 protein coding gene Chr12:110532477-110569489 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020498
 protein coding gene Chr12:114619993-114657389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018110
 protein coding gene Chr12:103494216-103530405 (-)
CAST/EiJ MGP_CASTEiJ_G0019397
 protein coding gene Chr12:105472133-105513426 (-)
CBA/J MGP_CBAJ_G0019822
 protein coding gene Chr12:119204201-119244731 (-)
DBA/2J MGP_DBA2J_G0019939
 protein coding gene Chr12:106508769-106544842 (-)
FVB/NJ MGP_FVBNJ_G0019924
 protein coding gene Chr12:105303394-105339816 (-)
LP/J MGP_LPJ_G0020014
 protein coding gene Chr12:111067479-111105154 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019962
 protein coding gene Chr12:122324083-122362973 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020527
 protein coding gene Chr12:109556778-109593558 (-)
PWK/PhJ MGP_PWKPhJ_G0019156
 protein coding gene Chr12:101133889-101171945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018960
 protein coding gene Chr12:103766355-103788034 (-)
WSB/EiJ MGP_WSBEiJ_G0019454
 protein coding gene Chr12:110500001-110539045 (-)



Homology
more
  • Human Ortholog
    BEGAIN, brain enriched guanylate kinase associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BEGAIN, brain enriched guanylate kinase associated
  • Links
    NCBI Gene ID: 57596
    neXtProt AC: NX_Q9BUH8
    UniProt: Q9BUH8

  • Chr Location
    14q32.2; chr14:100537147-100587417 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormal evoked NMDAR excitatory postsynaptic currents, and abnormalities in long-term spatial reference memory, extinction of fear memory and pain thresholds after injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    10
  • cDNA Data
    15
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040867 Ensembl Gene Model | MGI Sequence Detail 36031 C57BL/6J ±  kb
transcript ENSMUST00000209829 Ensembl | MGI Sequence Detail 3272 Not Applicable  
polypeptide ENSMUSP00000148247 Ensembl | MGI Sequence Detail 824 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004720 brain-enriched guanylate kinase-associated protein
    (term hierarchy)
  • InterPro Domains
    IPR043441 Junction-associated protein Tjap1/BEGAIN
  • GlyGen
    Q68EF6 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685743
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory