Tlr13 MGI Mouse Gene Detail - MGI:3045213

Symbol

Tlr13
Name

toll-like receptor 13
Synonyms

LOC279572

Feature Type

protein coding gene
IDs

MGI:3045213
NCBI Gene: 279572
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

ChrX:105186881-105204099 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.36 cM
Mapping Data

2 experiments

SNPs within 2kb

379 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045213	protein coding gene	ChrX:105186810-105204099 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036003	protein coding gene	ChrX:102931051-102952280 (+)
A/J	MGP_AJ_G0035982	protein coding gene	ChrX:102699424-102722421 (+)
AKR/J	MGP_AKRJ_G0035901	protein coding gene	ChrX:105990827-106009851 (+)
BALB/cJ	MGP_BALBcJ_G0035972	protein coding gene	ChrX:101539658-101557911 (+)
C3H/HeJ	MGP_C3HHeJ_G0035679	protein coding gene	ChrX:103364001-103382233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036499	protein coding gene	ChrX:105866884-105885397 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033327	protein coding gene	ChrX:100169723-100186588 (+)
CAST/EiJ	MGP_CASTEiJ_G0034966	protein coding gene	ChrX:87513050-87531392 (+)
CBA/J	MGP_CBAJ_G0035654	protein coding gene	ChrX:109190801-109208742 (+)
DBA/2J	MGP_DBA2J_G0035808	protein coding gene	ChrX:101987710-102005004 (+)
FVB/NJ	MGP_FVBNJ_G0035749	protein coding gene	ChrX:101306541-101325214 (+)
LP/J	MGP_LPJ_G0035901	protein coding gene	ChrX:103898153-103917261 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035781	protein coding gene	ChrX:113875435-113893863 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036525	protein coding gene	ChrX:102562578-102581513 (+)
PWK/PhJ	MGP_PWKPhJ_G0034662	protein coding gene	ChrX:85041776-85059468 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034491	protein coding gene	ChrX:88253838-88272605 (+)
WSB/EiJ	MGP_WSBEiJ_G0035104	protein coding gene	ChrX:101268884-101286366 (+)

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MGI Vertebrate Homology

Tlr13 stringent orthology
1 mouse;1 rat;1 zebrafish
Gene Tree

Tlr13

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Macrophages isolated from mice carrying an ENU-induced mutation respond normally to known TLR ligands and can contain various viral infections; however, mice carrying this allele have not been tested for immune responses in vivo.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tlr13

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS30338.1

Ensembl

ENSMUSG00000033777 (Evidence)
NCBI Gene

279572

			Length	Strain/Species	Flank
genomic	279572	NCBI Gene Model \| MGI Sequence Detail	17219	C57BL/6J	± kb
transcript	NM_205820	RefSeq \| MGI Sequence Detail	4014	C57BL/6
polypeptide	Q6R5N8	UniProt \| EBI \| MGI Sequence Detail	991	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016929 Toll-like receptor 13

(term hierarchy)
PDB

4Z0C
InterPro Domains

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily

IPR017241 Toll-like receptor
GlyGen

Q6R5N8 21 sites, 6 N-linked glycans (15 sites)

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2147911, MGI:2685559

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 20
Earliest

J:88906 Tabeta K, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
Latest

J:354595 Rafique A, et al., Toll-like receptor 13-mediated signaling protects against the development of colon cancer. Int J Cancer. 2024 Jul 11;

TSS for Tlr13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161781	ChrX:105186805-105186820 (+)	-68 bp
Tssr161782	ChrX:105186849-105186908 (+)	-2 bp
Tssr161783	ChrX:105187291-105187300 (+)	415 bp
Tssr161784	ChrX:105187478-105187483 (+)	600 bp
Tssr161785	ChrX:105190248-105190258 (+)	3,372 bp
Tssr161786	ChrX:105193266-105193274 (+)	6,389 bp
Tssr161787	ChrX:105200349-105200361 (+)	13,474 bp
Tssr161788	ChrX:105200391-105200415 (+)	13,522 bp
Tssr161789	ChrX:105200435-105200453 (+)	13,563 bp
Tssr161790	ChrX:105200455-105200482 (+)	13,588 bp
Tssr161791	ChrX:105200705-105200717 (+)	13,830 bp
Tssr161792	ChrX:105201040-105201055 (+)	14,167 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24