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Tlr12 Gene Detail
Summary
  • Symbol
    Tlr12
  • Name
    toll-like receptor 12
  • Synonyms
    LOC384059, Tlr11
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045221
    NCBI Gene: 384059
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128509239-128512412 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 62.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045221
 protein coding gene Chr4:128509236-128512412 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028804
 protein coding gene Chr4:130432564-130435740 (-)
A/J MGP_AJ_G0028763
 protein coding gene Chr4:125276564-125279740 (-)
AKR/J MGP_AKRJ_G0028716
 protein coding gene Chr4:128744279-128747455 (-)
BALB/cJ MGP_BALBcJ_G0028786
 protein coding gene Chr4:125858368-125861544 (-)
C3H/HeJ MGP_C3HHeJ_G0028500
 protein coding gene Chr4:128792851-128796027 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029228
 protein coding gene Chr4:135378838-135382014 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026501
 protein coding gene Chr4:118409926-118413105 (-)
CAST/EiJ MGP_CASTEiJ_G0027933
 protein coding gene Chr4:126964590-126967766 (-)
CBA/J MGP_CBAJ_G0028466
 protein coding gene Chr4:138669064-138672240 (-)
DBA/2J MGP_DBA2J_G0028615
 protein coding gene Chr4:125711242-125714418 (-)
FVB/NJ MGP_FVBNJ_G0028582
 protein coding gene Chr4:124456244-124459420 (-)
LP/J MGP_LPJ_G0028716
 protein coding gene Chr4:130744475-130747651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028608
 protein coding gene Chr4:143608253-143611429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029266
 protein coding gene Chr4:129114747-129117923 (-)
PWK/PhJ MGP_PWKPhJ_G0027654
 protein coding gene Chr4:122270902-122274078 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027481
 protein coding gene Chr4:124962558-124965734 (-)
WSB/EiJ MGP_WSBEiJ_G0028013
 protein coding gene Chr4:129214446-129217622 (-)



Homology
more
  • Human Ortholog
    TLR12P, toll like receptor 12, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR12P, toll like receptor 12, pseudogene
  • Links
    NCBI Gene ID: 100131451

  • Chr Location
    1p35.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit a greatly increased susceptibility to kidney infection by uropathogenic bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 384059 NCBI Gene Model | MGI Sequence Detail 3174 C57BL/6J ±  kb
transcript NM_205823 RefSeq | MGI Sequence Detail 3174 C57BL/6  
polypeptide Q6QNU9 UniProt | EBI | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016928 Toll-like receptor 12
    (term hierarchy)
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
    IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    IPR017241 Toll-like receptor
  • GlyGen
    Q6QNU9 4 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGI:2686211
References
more
  • Summaries
    All 59
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 33
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory