Morc2b MGI Mouse Gene Detail - MGI:3045293

Symbol

Morc2b
Name

microrchidia 2B
Synonyms

4932411A10Rik

Feature Type

protein coding gene
IDs

MGI:3045293
NCBI Gene: 240069
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:33354562-33369473 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

1 experiment

SNPs within 2kb

468 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045293	protein coding gene	Chr17:33332325-33369473 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023522	protein coding gene	Chr17:33036950-33041043 (-)
A/J	MGP_AJ_G0023480	protein coding gene	Chr17:31937789-31941880 (-)
AKR/J	MGP_AKRJ_G0023446	protein coding gene	Chr17:32249027-32253118 (-)
BALB/cJ	MGP_BALBcJ_G0023485	protein coding gene	Chr17:32038169-32042267 (-)
C3H/HeJ	MGP_C3HHeJ_G0023248	protein coding gene	Chr17:32638140-32642227 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023928	protein coding gene	Chr17:34160172-34164265 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021402	protein coding gene	Chr17:29496982-29501088 (-)
CAST/EiJ	MGP_CASTEiJ_G0022748	protein coding gene	Chr17:32745536-32749622 (-)
CBA/J	MGP_CBAJ_G0023221	protein coding gene	Chr17:35671548-35675631 (-)
DBA/2J	MGP_DBA2J_G0023351	protein coding gene	Chr17:31310906-31315017 (-)
FVB/NJ	MGP_FVBNJ_G0023321	protein coding gene	Chr17:31119553-31123645 (-)
LP/J	MGP_LPJ_G0023430	protein coding gene	Chr17:33257957-33262058 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023340	protein coding gene	Chr17:34662523-34666615 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023970	protein coding gene	Chr17:32618520-32622621 (-)
PWK/PhJ	MGP_PWKPhJ_G0022495	protein coding gene	Chr17:30235491-30239648 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022315	protein coding gene	Chr17:30586656-30590748 (-)
WSB/EiJ	MGP_WSBEiJ_G0022809	protein coding gene	Chr17:32623976-32628066 (-)

Human Ortholog

MORC2, MORC family CW-type zinc finger 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MORC2, MORC family CW-type zinc finger 2
Synonyms

CMT2Z, DIGFAN, ZCW3, ZCWCC1
Links

HGNC:23573

NCBI Gene ID: 22880

neXtProt AC: NX_Q9Y6X9

UniProt: Q9Y6X9
Chr Location

22q12.2; chr22:30925130-30968774 (-) GRCh38

MGI Vertebrate Homology

Morc2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MORC2
Gene Tree

Morc2b

Diseases

1 with human MORC2 associations

Human Disease

Mouse Models

Charcot-Marie-Tooth disease axonal type 2Z

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display male and female infertility with failure of chromosomal synapsis, double strand break repair, and recombination in meiosis.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

23
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

10
UniProt

2
CCDS

CCDS37561.1

Ensembl

ENSMUSG00000048602 (Evidence)
NCBI Gene

240069

			Length	Strain/Species	Flank
genomic	240069	NCBI Gene Model \| MGI Sequence Detail	14912	C57BL/6J	± kb
transcript	NM_001360203	RefSeq \| MGI Sequence Detail	3953	C57BL/6
polypeptide	Q8C5W4	UniProt \| EBI \| MGI Sequence Detail	1022	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000034194 ATPase MORC2B

(term hierarchy)
EC

3.6.1.-
InterPro Domains

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR041006 Morc, S5 domain 2-like

IPR011124 Zinc finger, CW-type

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 2

Summaries

All 24

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 1
Earliest

J:102875 Hayashi K, et al., A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005 Nov 17;438(7066):374-8
Latest

J:256987 Shi B, et al., MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018 Jan;14(1):e1007175

TSS for Morc2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147434	Chr17:33358646-33358649 (-)	10,825 bp
Tssr147433	Chr17:33358591-33358644 (-)	10,855 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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