Zc3h12d MGI Mouse Gene Detail - MGI:3045313 - zinc finger CCCH type containing 12D

Symbol

Zc3h12d
Name

zinc finger CCCH type containing 12D
Synonyms

D730019B10Rik, TFL

Feature Type

protein coding gene
IDs

MGI:3045313
NCBI Gene: 237256
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:7708234-7746160 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.44 cM
Mapping Data

1 experiment

SNPs within 2kb

1275 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045313	protein coding gene	Chr10:7708087-7746161 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017001	protein coding gene	Chr10:5060425-5103682 (+)
A/J	MGP_AJ_G0016979	protein coding gene	Chr10:4813497-4851800 (+)
AKR/J	MGP_AKRJ_G0016943	protein coding gene	Chr10:4908515-4948592 (+)
BALB/cJ	MGP_BALBcJ_G0016937	protein coding gene	Chr10:4784419-4822816 (+)
C3H/HeJ	MGP_C3HHeJ_G0016762	protein coding gene	Chr10:5040583-5086504 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017399	protein coding gene	Chr10:5184491-5238077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015104	protein coding gene	Chr10:4406461-4438171 (+)
CAST/EiJ	MGP_CASTEiJ_G0016344	protein coding gene	Chr10:4955714-5008438 (+)
CBA/J	MGP_CBAJ_G0016734	protein coding gene	Chr10:5336552-5382392 (+)
DBA/2J	MGP_DBA2J_G0016842	protein coding gene	Chr10:4740697-4779432 (+)
FVB/NJ	MGP_FVBNJ_G0016837	protein coding gene	Chr10:4687877-4726433 (+)
LP/J	MGP_LPJ_G0016917	protein coding gene	Chr10:4906141-4944505 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016867	protein coding gene	Chr10:5290675-5335408 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017437	protein coding gene	Chr10:4859300-4898897 (+)
PWK/PhJ	MGP_PWKPhJ_G0016129	protein coding gene	Chr10:4717587-4756255 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015911	protein coding gene	Chr10:4942584-4979432 (+)
WSB/EiJ	MGP_WSBEiJ_G0016406	protein coding gene	Chr10:4862329-4902510 (+)

Human Ortholog

ZC3H12D, zinc finger CCCH-type containing 12D

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H12D, zinc finger CCCH-type containing 12D
Synonyms

C6orf95, dJ281H8.1, MCPIP4, p34, TFL
Links

HGNC:21175

NCBI Gene ID: 340152

neXtProt AC: NX_A2A288

UniProt: A2A288
Chr Location

chr6:149446795-149485014 (-) GRCh38

MGI Vertebrate Homology

Zc3h12d stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZC3H12D
Gene Tree

Zc3h12d

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit disrupted regulation of excessive inflammation.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

6
UniProt

2
CCDS

CCDS48496.1

Ensembl

ENSMUSG00000039981 (Evidence)
NCBI Gene

237256

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039981	Ensembl Gene Model \| MGI Sequence Detail	37927	C57BL/6J	± kb
transcript	ENSMUST00000039484	Ensembl \| MGI Sequence Detail	4092	Not Applicable
polypeptide	ENSMUSP00000040217	Ensembl \| MGI Sequence Detail	533	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030420 probable ribonuclease ZC3H12D

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR040546 Rege-1, UBA-like domain

IPR021869 Ribonuclease Zc3h12a-like, NYN domain

IPR051101 ZC3H12/N4BP1 Ribonuclease and Regulator

IPR000571 Zinc finger, CCCH-type

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 33

Gene Ontology 7

Phenotypes 10
Earliest

J:140125 Liang J, et al., Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS One. 2008;3(8):e2880
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zc3h12d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92322	Chr10:7708079-7708089 (+)	-150 bp
Tssr92323	Chr10:7708090-7708131 (+)	-123 bp
Tssr92324	Chr10:7708178-7708218 (+)	-36 bp
Tssr92325	Chr10:7708221-7708255 (+)	4 bp
Tssr92326	Chr10:7708271-7708284 (+)	44 bp
Tssr92327	Chr10:7712232-7712251 (+)	4,008 bp
Tssr92328	Chr10:7715451-7715476 (+)	7,230 bp
Tssr92329	Chr10:7734357-7734366 (+)	26,128 bp
Tssr92330	Chr10:7737854-7737867 (+)	29,627 bp
Tssr92331	Chr10:7744637-7744642 (+)	36,406 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24