Ccin MGI Mouse Gene Detail - MGI:3045316

Symbol

Ccin
Name

calicin
Synonyms

4933417A14Rik

Feature Type

protein coding gene
IDs

MGI:3045316
NCBI Gene: 442829
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:43983483-43985423 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.08 cM
Mapping Data

1 experiment

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045316	protein coding gene	Chr4:43983483-43985533 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028230	protein coding gene	Chr4:42116213-42118153 (+)
A/J	MGP_AJ_G0028187	protein coding gene	Chr4:40625652-40627592 (+)
AKR/J	MGP_AKRJ_G0028139	protein coding gene	Chr4:41580589-41582529 (+)
BALB/cJ	MGP_BALBcJ_G0028207	protein coding gene	Chr4:40722547-40724487 (+)
C3H/HeJ	MGP_C3HHeJ_G0027929	protein coding gene	Chr4:42192599-42194539 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028648	protein coding gene	Chr4:43730441-43732381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025958	protein coding gene	Chr4:38060715-38062655 (+)
CAST/EiJ	MGP_CASTEiJ_G0027368	protein coding gene	Chr4:41710936-41712876 (+)
CBA/J	MGP_CBAJ_G0027895	protein coding gene	Chr4:45077384-45079324 (+)
DBA/2J	MGP_DBA2J_G0028044	protein coding gene	Chr4:40535954-40537894 (+)
FVB/NJ	MGP_FVBNJ_G0028011	protein coding gene	Chr4:39767177-39769117 (+)
LP/J	MGP_LPJ_G0028143	protein coding gene	Chr4:42199788-42201728 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028035	protein coding gene	Chr4:48279243-48281183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028684	protein coding gene	Chr4:41791284-41793224 (+)
PWK/PhJ	MGP_PWKPhJ_G0027092	protein coding gene	Chr4:40583641-40585581 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026921	protein coding gene	Chr4:41315828-41317768 (+)
WSB/EiJ	MGP_WSBEiJ_G0027446	protein coding gene	Chr4:41668908-41670848 (+)

Human Ortholog

CCIN, calicin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCIN, calicin
Synonyms

BTBD20, KBTBD14, SPGF91
Links

HGNC:1568

NCBI Gene ID: 881

neXtProt AC: NX_Q13939

UniProt: Q13939
Chr Location

9p13.3; chr9:36169388-36171334 (+) GRCh38

MGI Vertebrate Homology

Ccin stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CCIN
Gene Tree

Ccin

Diseases

1 with human CCIN associations

				Human Disease	Mouse Models
				spermatogenic failure 91 IDs spermatogenic failure 91 DOID:0070590 OMIM:620838

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically and radiation induced

1
Endonuclease-mediated

4
Genomic Mutations

1 involving Ccin
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility associated with oligozoospermia, asthenozoospermia, defective acroplaxome structure, and increased male germ cell apoptosis.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS18118.1

Ensembl

ENSMUSG00000070999 (Evidence)
NCBI Gene

442829

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070999	Ensembl Gene Model \| MGI Sequence Detail	1941	C57BL/6J	± kb
transcript	ENSMUST00000095107	Ensembl \| MGI Sequence Detail	1941	Not Applicable
polypeptide	ENSMUSP00000092725	Ensembl \| MGI Sequence Detail	588	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005109 calicin

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR000210 BTB/POZ domain

IPR048070 Calicin, BTB/POZ

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 23

Gene Ontology 4

Phenotypes 4
Earliest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Latest

J:352417 Fan Y, et al., Mutations in CCIN cause teratozoospermia and male infertility. Sci Bull (Beijing). 2022 Oct 31;67(20):2112-2123

TSS for Ccin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37010	Chr4:43983473-43983491 (+)	-1 bp
Tssr37011	Chr4:43983496-43983523 (+)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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