Usp44 MGI Mouse Gene Detail - MGI:3045318 - ubiquitin specific peptidase 44

Symbol

Usp44
Name

ubiquitin specific peptidase 44
Synonyms

E430004F17Rik

Feature Type

protein coding gene
IDs

MGI:3045318
NCBI Gene: 327799
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:93667417-93693950 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 48.67 cM
Mapping Data

1 experiment

SNPs within 2kb

953 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045318	protein coding gene	Chr10:93655831-93696792 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017657	protein coding gene	Chr10:95258152-95278355 (+)
A/J	MGP_AJ_G0017636	protein coding gene	Chr10:91943262-91960965 (+)
AKR/J	MGP_AKRJ_G0017594	protein coding gene	Chr10:94567992-94586587 (+)
BALB/cJ	MGP_BALBcJ_G0017599	protein coding gene	Chr10:92211085-92228877 (+)
C3H/HeJ	MGP_C3HHeJ_G0017422	protein coding gene	Chr10:94570069-94587652 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018056	protein coding gene	Chr10:98429098-98447333 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015737	protein coding gene	Chr10:87533013-87548285 (+)
CAST/EiJ	MGP_CASTEiJ_G0016987	protein coding gene	Chr10:94564311-94582509 (+)
CBA/J	MGP_CBAJ_G0017391	protein coding gene	Chr10:102494686-102512215 (+)
DBA/2J	MGP_DBA2J_G0017497	protein coding gene	Chr10:91033356-91051363 (+)
FVB/NJ	MGP_FVBNJ_G0017489	protein coding gene	Chr10:90255793-90279395 (+)
LP/J	MGP_LPJ_G0017571	protein coding gene	Chr10:95875890-95894424 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017520	protein coding gene	Chr10:103764589-103783776 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018093	protein coding gene	Chr10:94470879-94490837 (+)
PWK/PhJ	MGP_PWKPhJ_G0016768	protein coding gene	Chr10:91128348-91146226 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016557	protein coding gene	Chr10:93285649-93302917 (+)
WSB/EiJ	MGP_WSBEiJ_G0017046	protein coding gene	Chr10:94441963-94459590 (+)

Human Ortholog

USP44, ubiquitin specific peptidase 44

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP44, ubiquitin specific peptidase 44
Links

HGNC:20064

NCBI Gene ID: 84101

neXtProt AC: NX_Q9H0E7

UniProt: Q9H0E7
Chr Location

12q22; chr12:95516560-95551681 (-) GRCh38

MGI Vertebrate Homology

Usp44 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP44
Gene Tree

Usp44

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
3 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Targeted

8
Transposon induced

1
Genomic Mutations

2 involving Usp44
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit chromosomal instability, aneuploidy and increased tumor incidence.

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All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA USP44

Xenbase usp44

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All Sequences

62
RefSeq

34
UniProt

1
CCDS

CCDS24129.1, CCDS88075.1

Ensembl

ENSMUSG00000020020 (Evidence)
NCBI Gene

327799

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020020	Ensembl Gene Model \| MGI Sequence Detail	26534	C57BL/6J	± kb
transcript	ENSMUST00000216224	Ensembl \| MGI Sequence Detail	2449	Not Applicable
polypeptide	ENSMUSP00000149020	Ensembl \| MGI Sequence Detail	711	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017183 ubiquitin carboxyl-terminal hydrolase 44

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050185 Ubiquitin carboxyl-terminal hydrolase

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001607 Zinc finger, UBP-type

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 43

Gene Ontology 10

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357573 Liu Y, et al., USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21. Int J Biol Sci. 2024;20(13):5223-5238

TSS for Usp44:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95286	Chr10:93667303-93667314 (+)	-108 bp
Tssr95287	Chr10:93669644-93669679 (+)	2,245 bp
Tssr95288	Chr10:93669680-93669692 (+)	2,269 bp
Tssr95289	Chr10:93669703-93669723 (+)	2,296 bp
Tssr95290	Chr10:93669771-93669815 (+)	2,376 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24