Trim67 MGI Mouse Gene Detail - MGI:3045323 - tripartite motif-containing 67

Symbol

Trim67
Name

tripartite motif-containing 67
Synonyms

D130049O21Rik

Feature Type

protein coding gene
IDs

MGI:3045323
NCBI Gene: 330863
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:125519831-125561452 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.81 cM
Mapping Data

1 experiment

SNPs within 2kb

1435 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045323	protein coding gene	Chr8:125519758-125561452 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034278	protein coding gene	Chr8:128501543-128546969 (+)
A/J	MGP_AJ_G0034258	protein coding gene	Chr8:123177431-123214935 (+)
AKR/J	MGP_AKRJ_G0034185	protein coding gene	Chr8:126730346-126776498 (+)
BALB/cJ	MGP_BALBcJ_G0034251	protein coding gene	Chr8:123358851-123400662 (+)
C3H/HeJ	MGP_C3HHeJ_G0033962	protein coding gene	Chr8:127376665-127423928 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034771	protein coding gene	Chr8:132790364-132833797 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031712	protein coding gene	Chr8:115936482-115977072 (+)
CAST/EiJ	MGP_CASTEiJ_G0033289	protein coding gene	Chr8:127499493-127546851 (+)
CBA/J	MGP_CBAJ_G0033935	protein coding gene	Chr8:137665819-137711882 (+)
DBA/2J	MGP_DBA2J_G0034091	protein coding gene	Chr8:122333526-122375875 (+)
FVB/NJ	MGP_FVBNJ_G0034035	protein coding gene	Chr8:121511984-121557129 (+)
LP/J	MGP_LPJ_G0034180	protein coding gene	Chr8:128663013-128706237 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034082	protein coding gene	Chr8:139749928-139795110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034790	protein coding gene	Chr8:126969959-127014349 (+)
PWK/PhJ	MGP_PWKPhJ_G0032991	protein coding gene	Chr8:122093946-122137285 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032830	protein coding gene	Chr8:125590795-125641844 (+)
WSB/EiJ	MGP_WSBEiJ_G0033406	protein coding gene	Chr8:127687221-127732142 (+)

Human Ortholog

TRIM67, tripartite motif containing 67

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM67, tripartite motif containing 67
Synonyms

TNL
Links

HGNC:31859

NCBI Gene ID: 440730

neXtProt AC: NX_Q6ZTA4

UniProt: Q6ZTA4
Chr Location

1q42.2; chr1:231162058-231221565 (+) GRCh38

MGI Vertebrate Homology

Trim67 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TRIM67
Gene Tree

Trim67

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display decreased brain size with forebrain abnormalities, impaired spatial learning, decreased response to social novelty, impaired coordiation and reduced grip strength.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

33
cDNA Data

67
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim67

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS52704.1

Ensembl

ENSMUSG00000036913 (Evidence)
NCBI Gene

330863

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036913	Ensembl Gene Model \| MGI Sequence Detail	41622	C57BL/6J	± kb
transcript	ENSMUST00000167588	Ensembl \| MGI Sequence Detail	8735	Not Applicable
polypeptide	ENSMUSP00000130343	Ensembl \| MGI Sequence Detail	768	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032659 tripartite motif-containing protein 67

(term hierarchy)
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR003649 B-box, C-terminal

IPR000315 B-box-type zinc finger

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR017903 COS domain

IPR050617 E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR003877 SPRY domain

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site
GlyGen

Q505D9 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 67

cDNA 67

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 10
Earliest

J:185071 Yaguchi H, et al., TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. J Biol Chem. 2012 Apr 6;287(15):12050-9
Latest

J:340527 Cai C, et al., TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb. Int J Mol Sci. 2023 Aug 30;24(17)

TSS for Trim67:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80035	Chr8:125519712-125519719 (+)	-115 bp
Tssr80036	Chr8:125519752-125519795 (+)	-57 bp
Tssr80037	Chr8:125519800-125519809 (+)	-26 bp
Tssr80038	Chr8:125520230-125520253 (+)	411 bp
Tssr80039	Chr8:125520529-125520560 (+)	714 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24