Slfnl1 MGI Mouse Gene Detail - MGI:3045330

Symbol

Slfnl1
Name

schlafen like 1
Synonyms

4933406A14Rik

Feature Type

protein coding gene
IDs

MGI:3045330
NCBI Gene: 194219
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:120389446-120393858 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 56.52 cM
Mapping Data

1 experiment

SNPs within 2kb

193 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045330	protein coding gene	Chr4:120389428-120393858 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028709	protein coding gene	Chr4:121792018-121796448 (+)
A/J	MGP_AJ_G0028669	protein coding gene	Chr4:116998297-117002727 (+)
AKR/J	MGP_AKRJ_G0028622	protein coding gene	Chr4:119558392-119562822 (+)
BALB/cJ	MGP_BALBcJ_G0028692	protein coding gene	Chr4:117605809-117610239 (+)
C3H/HeJ	MGP_C3HHeJ_G0028407	protein coding gene	Chr4:121095577-121100007 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029133	protein coding gene	Chr4:126385231-126389661 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026410	protein coding gene	Chr4:111069739-111074171 (+)
CAST/EiJ	MGP_CASTEiJ_G0027838	protein coding gene	Chr4:118461273-118465676 (+)
CBA/J	MGP_CBAJ_G0028374	protein coding gene	Chr4:129816152-129820582 (+)
DBA/2J	MGP_DBA2J_G0028521	protein coding gene	Chr4:117578409-117582839 (+)
FVB/NJ	MGP_FVBNJ_G0028487	protein coding gene	Chr4:116106365-116110795 (+)
LP/J	MGP_LPJ_G0028621	protein coding gene	Chr4:121917442-121921872 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028515	protein coding gene	Chr4:134653765-134658195 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029170	protein coding gene	Chr4:120629846-120634276 (+)
PWK/PhJ	MGP_PWKPhJ_G0027561	protein coding gene	Chr4:114523045-114527445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027387	protein coding gene	Chr4:117064727-117069118 (+)
WSB/EiJ	MGP_WSBEiJ_G0027918	protein coding gene	Chr4:120639282-120643712 (+)

Human Ortholog

SLFNL1, schlafen like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLFNL1, schlafen like 1
Links

HGNC:26313

NCBI Gene ID: 200172

neXtProt AC: NX_Q499Z3

UniProt: Q499Z3
Chr Location

1p34.2; chr1:41015589-41023237 (-) GRCh38

MGI Vertebrate Homology

Slfnl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLFNL1
Gene Tree

Slfnl1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Slfnl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice exhibit normal fertility.

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS18590.1

Ensembl

ENSMUSG00000047518 (Evidence)
NCBI Gene

194219

			Length	Strain/Species	Flank
genomic	194219	NCBI Gene Model \| MGI Sequence Detail	4413	C57BL/6J	± kb
transcript	NM_177570	RefSeq \| MGI Sequence Detail	1744	C57BL/6
polypeptide	Q8BHW9	UniProt \| EBI \| MGI Sequence Detail	410	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015232 Schlafen-like protein 1

(term hierarchy)
InterPro Domains

IPR007421 Schlafen, AlbA_2 domain

IPR038461 Schlafen, AlbA_2 domain superfamily

IPR029684 Schlafen family

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 11
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:296968 Park S, et al., CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. Biol Reprod. 2020 Aug 4;103(2):195-204

TSS for Slfnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38796	Chr4:120389416-120389453 (+)	-11 bp
Tssr38797	Chr4:120389457-120389462 (+)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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