Mettl24 MGI Mouse Gene Detail - MGI:3045338

Symbol

Mettl24
Name

methyltransferase like 24
Synonyms

9030224M15Rik

Feature Type

protein coding gene
IDs

MGI:3045338
NCBI Gene: 327747
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:40559278-40687079 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.02 cM
Mapping Data

1 experiment

SNPs within 2kb

3806 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045338	protein coding gene	Chr10:40558447-40687080 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017166	protein coding gene	Chr10:39288167-39423748 (+)
A/J	MGP_AJ_G0017143	protein coding gene	Chr10:38194453-38328723 (+)
AKR/J	MGP_AKRJ_G0017103	protein coding gene	Chr10:38749327-38883822 (+)
BALB/cJ	MGP_BALBcJ_G0017105	protein coding gene	Chr10:38278370-38410883 (+)
C3H/HeJ	MGP_C3HHeJ_G0016926	protein coding gene	Chr10:39072144-39206858 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017564	protein coding gene	Chr10:40500940-40638862 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015260	protein coding gene	Chr10:36160743-36292139 (+)
CAST/EiJ	MGP_CASTEiJ_G0016505	protein coding gene	Chr10:39271718-39411537 (+)
CBA/J	MGP_CBAJ_G0016900	protein coding gene	Chr10:42330815-42487412 (+)
DBA/2J	MGP_DBA2J_G0017005	protein coding gene	Chr10:37715587-37843568 (+)
FVB/NJ	MGP_FVBNJ_G0017000	protein coding gene	Chr10:37207214-37339392 (+)
LP/J	MGP_LPJ_G0017082	protein coding gene	Chr10:39272442-39407240 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017030	protein coding gene	Chr10:43167471-43305453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017601	protein coding gene	Chr10:38727515-38863905 (+)
PWK/PhJ	MGP_PWKPhJ_G0016285	protein coding gene	Chr10:37595088-37731978 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016069	protein coding gene	Chr10:38561697-38697665 (+)
WSB/EiJ	MGP_WSBEiJ_G0016568	protein coding gene	Chr10:39073186-39203643 (+)

Human Ortholog

METTL24, methyltransferase like 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METTL24, methyltransferase like 24
Synonyms

C6orf186
Links

HGNC:21566

NCBI Gene ID: 728464

neXtProt AC: NX_Q5JXM2

UniProt: Q5JXM2
Chr Location

6q21

MGI Vertebrate Homology

Mettl24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: METTL24
Gene Tree

Mettl24

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mettl24
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mettl24

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All Sequences

46
RefSeq

18
UniProt

1
CCDS

CCDS23799.1

Ensembl

ENSMUSG00000045555 (Evidence)
NCBI Gene

327747

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045555	Ensembl Gene Model \| MGI Sequence Detail	127802	C57BL/6J	± kb
transcript	ENSMUST00000058747	Ensembl \| MGI Sequence Detail	1529	Not Applicable
polypeptide	ENSMUSP00000049997	Ensembl \| MGI Sequence Detail	363	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031615 probable methyltransferase-like protein 24

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR025714 Methyltransferase domain

IPR026913 Probable methyltransferase-like protein 24

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All nucleic 5

cDNA 5

Microarray probesets 3

Summaries

All 34

Gene Ontology 2

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mettl24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93029	Chr10:40559249-40559263 (+)	-22 bp
Tssr93030	Chr10:40579674-40579692 (+)	20,405 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24