Dynlt4 MGI Mouse Gene Detail - MGI:3045358 - dynein light chain Tctex-type 4

Symbol

Dynlt4
Name

dynein light chain Tctex-type 4
Synonyms

4833401D15Rik, Tctex1d4

Feature Type

protein coding gene
IDs

MGI:3045358
NCBI Gene: 242646
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:116983991-116985935 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.41 cM
Mapping Data

1 experiment

SNPs within 2kb

98 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045358	protein coding gene	Chr4:116981734-116985935 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028644	protein coding gene	Chr4:118085863-118087807 (+)
A/J	MGP_AJ_G0028605	protein coding gene	Chr4:113537823-113539783 (+)
AKR/J	MGP_AKRJ_G0028555	protein coding gene	Chr4:116015630-116017574 (+)
BALB/cJ	MGP_BALBcJ_G0028626	protein coding gene	Chr4:114164809-114166767 (+)
C3H/HeJ	MGP_C3HHeJ_G0028340	protein coding gene	Chr4:117582644-117584602 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029067	protein coding gene	Chr4:122638114-122640058 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026351	protein coding gene	Chr4:107578199-107580160 (+)
CAST/EiJ	MGP_CASTEiJ_G0027774	protein coding gene	Chr4:114798530-114800485 (+)
CBA/J	MGP_CBAJ_G0028307	protein coding gene	Chr4:125991927-125993885 (+)
DBA/2J	MGP_DBA2J_G0028455	protein coding gene	Chr4:114173109-114175069 (+)
FVB/NJ	MGP_FVBNJ_G0028423	protein coding gene	Chr4:112672547-112674505 (+)
LP/J	MGP_LPJ_G0028557	protein coding gene	Chr4:118264576-118266520 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028450	protein coding gene	Chr4:130934623-130936567 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029104	protein coding gene	Chr4:117162972-117164916 (+)
PWK/PhJ	MGP_PWKPhJ_G0027500	protein coding gene	Chr4:110968431-110970325 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027323	protein coding gene	Chr4:113460716-113462690 (+)
WSB/EiJ	MGP_WSBEiJ_G0027853	protein coding gene	Chr4:117031650-117033610 (+)

Human Ortholog

DYNLT4, dynein light chain Tctex-type 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYNLT4, dynein light chain Tctex-type 4
Synonyms

TCTEX1D4
Links

HGNC:32315

NCBI Gene ID: 343521

neXtProt AC: NX_Q5JR98

UniProt: Q5JR98
Chr Location

1p34.1; chr1:44805893-44807351 (-) GRCh38

MGI Vertebrate Homology

Dynlt4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DYNLT4
Gene Tree

Dynlt4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Gene trapped

6
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Dynlt4
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

10
UniProt

3
CCDS

CCDS18528.1

Ensembl

ENSMUSG00000047671 (Evidence)
NCBI Gene

242646

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047671	Ensembl Gene Model \| MGI Sequence Detail	1945	C57BL/6J	± kb
transcript	ENSMUST00000062206	Ensembl \| MGI Sequence Detail	990	Not Applicable
polypeptide	ENSMUSP00000052243	Ensembl \| MGI Sequence Detail	219	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031293 dynein light chain Tctex-type 4

(term hierarchy)
InterPro Domains

IPR005334 Dynein light chain Tctex-1 like

IPR038586 Tctex-1-like superfamily

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:6458559

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 14
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dynlt4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38602	Chr4:116982130-116982178 (+)	-1,837 bp
Tssr38603	Chr4:116983964-116983971 (+)	-23 bp
Tssr38604	Chr4:116983973-116983994 (+)	-7 bp
Tssr38605	Chr4:116983997-116984015 (+)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24