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Defb22 Gene Detail
Summary
  • Symbol
    Defb22
  • Name
    defensin beta 22
  • Synonyms
    9230002F21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045368
    NCBI Gene: 442835
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152327586-152332058 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045368
 protein coding gene Chr2:152327583-152332058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026663
 protein coding gene Chr2:157047374-157051823 (-)
A/J MGP_AJ_G0026629
 protein coding gene Chr2:150771764-150777192 (-)
AKR/J MGP_AKRJ_G0026599
 protein coding gene Chr2:155179540-155183977 (-)
BALB/cJ MGP_BALBcJ_G0026638
 protein coding gene Chr2:151082555-151087050 (-)
C3H/HeJ MGP_C3HHeJ_G0026381
 protein coding gene Chr2:155558333-155563057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027087
 protein coding gene Chr2:161616484-161620906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024458
 protein coding gene Chr2:144363743-144368226 (-)
CAST/EiJ MGP_CASTEiJ_G0025842
 protein coding gene Chr2:155797485-155801835 (-)
CBA/J MGP_CBAJ_G0026359
 protein coding gene Chr2:167535416-167539670 (-)
DBA/2J MGP_DBA2J_G0026495
 protein coding gene Chr2:149989267-149993686 (-)
FVB/NJ MGP_FVBNJ_G0026461
 protein coding gene Chr2:148441271-148445702 (-)
LP/J MGP_LPJ_G0026599
 protein coding gene Chr2:157192546-157197043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026482
 protein coding gene Chr2:171635433-171640944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027143
 protein coding gene Chr2:155058065-155063634 (-)
PWK/PhJ MGP_PWKPhJ_G0025576
 protein coding gene Chr2:149506596-149511035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025379
 protein coding gene Chr2:153889864-153895732 (-)
WSB/EiJ MGP_WSBEiJ_G0025912
 protein coding gene Chr2:155978106-155982532 (-)



Homology
more
  • Human Ortholog
    DEFB126, defensin beta 126
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB126, defensin beta 126
  • Synonyms
    bA530N10.1, C20orf8, DEFB-26, DEFB26, hBD-26, HBD26
  • Links
    NCBI Gene ID: 81623
    neXtProt AC: NX_Q9BYW3
    UniProt: Q9BYW3

  • Chr Location
    20p13; chr20:142590-145751 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Defb22
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 442835 NCBI Gene Model | MGI Sequence Detail 4473 C57BL/6J ±  kb
transcript NM_001002791 RefSeq | MGI Sequence Detail 625 Not Specified  
polypeptide Q8BVC1 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025933 Beta-defensin
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory