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Lin52 Gene Detail
Summary
  • Symbol
    Lin52
  • Name
    lin-52 DREAM MuvB core complex component
  • Synonyms
    5830457H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045391
    NCBI Gene: 217708
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84498196-84592919 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2371 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045391
protein coding gene Chr12:84497965-84593293 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0019896
protein coding gene Chr12:81935700-82019561 (+)
AKR/J MGP_AKRJ_G0019872
protein coding gene Chr12:84152690-84235078 (+)
BALB/cJ MGP_BALBcJ_G0019876
protein coding gene Chr12:82268523-82347992 (+)
C3H/HeJ MGP_C3HHeJ_G0019682
protein coding gene Chr12:84618837-84652081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020327
protein coding gene Chr12:87612969-87704015 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017945
protein coding gene Chr12:78836179-78919528 (+)
CAST/EiJ MGP_CASTEiJ_G0019231
protein coding gene Chr12:79576899-79661680 (+)
CBA/J MGP_CBAJ_G0019653
protein coding gene Chr12:90996096-91080591 (+)
DBA/2J MGP_DBA2J_G0019768
protein coding gene Chr12:81464904-81545677 (+)
FVB/NJ MGP_FVBNJ_G0019754
protein coding gene Chr12:80420767-80499586 (+)
LP/J MGP_LPJ_G0019179
protein coding gene Chr11:108211850-108213686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019793
protein coding gene Chr12:93903976-93925396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020361
protein coding gene Chr12:83746329-83834293 (+)
PWK/PhJ MGP_PWKPhJ_G0018995
protein coding gene Chr12:75955529-76036212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018790
protein coding gene Chr12:78242491-78326014 (+)
WSB/EiJ MGP_WSBEiJ_G0018632
protein coding gene Chr11:106716435-106719458 (+)



Homology
more
  • Human Ortholog
    LIN52, lin-52 DREAM MuvB core complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN52, lin-52 DREAM MuvB core complex component
  • Synonyms
    c14_5549, C14orf46
  • Links
    NCBI Gene ID: 91750
    neXtProt AC: NX_Q52LA3
    UniProt: Q52LA3

  • Chr Location
    14q24.3; chr14:74084956-74201493 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000085793 Ensembl Gene Model | MGI Sequence Detail 94724 C57BL/6J ±  kb
    transcript ENSMUST00000221033 Ensembl | MGI Sequence Detail 498 Not Applicable  
    polypeptide ENSMUSP00000152849 Ensembl | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 1
      Phenotypes 16
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory