Nup85 MGI Mouse Gene Detail - MGI:3046173

Symbol

Nup85
Name

nucleoporin 85
Synonyms

frount, Pcnt1

Feature Type

protein coding gene
IDs

MGI:3046173
NCBI Gene: 445007
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:115455264-115474750 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.87 cM
Mapping Data

1 experiment

SNPs within 2kb

395 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3046173	protein coding gene	Chr11:115455260-115474811 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019393	protein coding gene	Chr11:119604213-119624347 (+)
A/J	MGP_AJ_G0019362	protein coding gene	Chr11:114380915-114400835 (+)
AKR/J	MGP_AKRJ_G0019332	protein coding gene	Chr11:117785559-117803794 (+)
BALB/cJ	MGP_BALBcJ_G0019336	protein coding gene	Chr11:114797241-114817945 (+)
C3H/HeJ	MGP_C3HHeJ_G0019142	protein coding gene	Chr11:118151978-118169158 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019786	protein coding gene	Chr11:123254127-123276227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017409	protein coding gene	Chr11:111409306-111425610 (+)
CAST/EiJ	MGP_CASTEiJ_G0018697	protein coding gene	Chr11:119464285-119487447 (+)
CBA/J	MGP_CBAJ_G0019114	protein coding gene	Chr11:128125321-128150965 (+)
DBA/2J	MGP_DBA2J_G0019225	protein coding gene	Chr11:113808739-113831498 (+)
FVB/NJ	MGP_FVBNJ_G0019217	protein coding gene	Chr11:113299283-113320396 (+)
LP/J	MGP_LPJ_G0019295	protein coding gene	Chr11:119989320-120009509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019250	protein coding gene	Chr11:127271402-127293086 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019824	protein coding gene	Chr11:118443085-118467790 (+)
PWK/PhJ	MGP_PWKPhJ_G0018461	protein coding gene	Chr11:115099740-115119534 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018254	protein coding gene	Chr11:118195588-118215850 (+)
WSB/EiJ	MGP_WSBEiJ_G0018749	protein coding gene	Chr11:118409766-118431952 (+)

Human Ortholog

NUP85, nucleoporin 85

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP85, nucleoporin 85
Synonyms

FROUNT, NPHS17, Nup75
Links

HGNC:8734

NCBI Gene ID: 79902

neXtProt AC: NX_Q9BW27

UniProt: Q9BW27
Chr Location

17q25.1; chr17:75205659-75235758 (+) GRCh38

MGI Vertebrate Homology

Nup85 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP85
Gene Tree

Nup85

Diseases

1 with human NUP85 associations

				Human Disease	Mouse Models
				nephrotic syndrome type 17 IDs nephrotic syndrome type 17 DOID:0080392 OMIM:618176

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Gene trapped

25
Targeted

5
Transgenic

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available

Inducible KO decreases macrophage and monocyte population in tumors, reducing tumor growth and metastasis.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

123
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup85

ZFIN nup85

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All Sequences

55
RefSeq

11
UniProt

3
CCDS

CCDS25640.1

Ensembl

ENSMUSG00000020739 (Evidence)
NCBI Gene

445007

			Length	Strain/Species	Flank
genomic	445007	NCBI Gene Model \| MGI Sequence Detail	19487	C57BL/6J	± kb
transcript	NM_001002929	RefSeq \| MGI Sequence Detail	2181	C57BL/6
polypeptide	Q8R480	UniProt \| EBI \| MGI Sequence Detail	656	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011523 nuclear pore complex protein Nup85

(term hierarchy)
InterPro Domains

IPR011502 Nucleoporin Nup85-like
GlyGen

Q8R480 1 site, 1 O-linked glycan (1 site)

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All nucleic 123

cDNA 123

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 12
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nup85:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105884	Chr11:115455263-115455316 (+)	26 bp
Tssr105885	Chr11:115472591-115472602 (+)	17,333 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24