Ano7 MGI Mouse Gene Detail - MGI:3052714

Symbol

Ano7
Name

anoctamin 7
Synonyms

IPCA-5, NGEP, NGEP-L, Pcanap5, Tmem16g

Feature Type

protein coding gene
IDs

MGI:3052714
NCBI Gene: 404545
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:93301652-93332025 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.24 cM
Mapping Data

1 experiment

SNPs within 2kb

860 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3052714	protein coding gene	Chr1:93301518-93332026 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016341	protein coding gene	Chr1:94995327-95029350 (+)
A/J	MGP_AJ_G0016322	protein coding gene	Chr1:91591776-91622027 (+)
AKR/J	MGP_AKRJ_G0016283	protein coding gene	Chr1:94292454-94328938 (+)
BALB/cJ	MGP_BALBcJ_G0016278	protein coding gene	Chr1:91773157-91804772 (+)
C3H/HeJ	MGP_C3HHeJ_G0016107	protein coding gene	Chr1:94549035-94582912 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016737	protein coding gene	Chr1:98612020-98643605 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014455	protein coding gene	Chr1:85848012-85879583 (+)
CAST/EiJ	MGP_CASTEiJ_G0015690	protein coding gene	Chr1:93882027-93913116 (+)
CBA/J	MGP_CBAJ_G0016081	protein coding gene	Chr1:101804397-101836547 (+)
DBA/2J	MGP_DBA2J_G0016186	protein coding gene	Chr1:90787112-90817612 (+)
FVB/NJ	MGP_FVBNJ_G0016185	protein coding gene	Chr1:89862200-89893849 (+)
LP/J	MGP_LPJ_G0016257	protein coding gene	Chr1:96171556-96206575 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016210	protein coding gene	Chr1:104906521-104938348 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016776	protein coding gene	Chr1:94310002-94343569 (+)
PWK/PhJ	MGP_PWKPhJ_G0015475	protein coding gene	Chr1:90226565-90257304 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015259	protein coding gene	Chr1:93265770-93296001 (+)
WSB/EiJ	MGP_WSBEiJ_G0015750	protein coding gene	Chr1:94131990-94163655 (+)

Human Ortholog

ANO7, anoctamin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANO7, anoctamin 7
Synonyms

D-TMPP, DTMPP, IPCA-5, IPCA5, NGEP, PCANAP5, PCANAP5L, TMEM16G
Links

HGNC:31677

NCBI Gene ID: 50636

neXtProt AC: NX_Q6IWH7

UniProt: Q6IWH7
Chr Location

2q37.3; chr2:241188509-241240308 (+) GRCh38

MGI Vertebrate Homology

Ano7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANO7
Gene Tree

Ano7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving Ano7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ano7

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All Sequences

45
RefSeq

15
UniProt

2
CCDS

CCDS15188.1, CCDS78656.1

Ensembl

ENSMUSG00000034107 (Evidence)
NCBI Gene

404545

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034107	Ensembl Gene Model \| MGI Sequence Detail	30374	C57BL/6J	± kb
transcript	ENSMUST00000186641	Ensembl \| MGI Sequence Detail	3984	Not Applicable
polypeptide	ENSMUSP00000140438	Ensembl \| MGI Sequence Detail	859	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004062 anoctamin-7

(term hierarchy)
InterPro Domains

IPR007632 Anoctamin

IPR032394 Anoctamin, dimerisation domain

IPR049452 Anoctamin, transmembrane domain
GlyGen

Q14AT5 2 sites

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 31

Gene Ontology 8

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ano7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8170	Chr1:93301518-93301529 (+)	-128 bp
Tssr8171	Chr1:93301532-93301561 (+)	-105 bp
Tssr8172	Chr1:93301566-93301582 (+)	-78 bp
Tssr8173	Chr1:93301586-93301593 (+)	-62 bp
Tssr8174	Chr1:93301596-93301621 (+)	-43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24