Lhfpl4 MGI Mouse Gene Detail - MGI:3057108 - lipoma HMGIC fusion partner-like protein 4

Symbol

Lhfpl4
Name

lipoma HMGIC fusion partner-like protein 4
Synonyms

1190004M23Rik

Feature Type

protein coding gene
IDs

MGI:3057108
NCBI Gene: 269788
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:113145051-113172345 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.74 cM
Mapping Data

2 experiments

SNPs within 2kb

689 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3057108	protein coding gene	Chr6:113145048-113172345 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031113	protein coding gene	Chr6:115662020-115693952 (-)
A/J	MGP_AJ_G0031082	protein coding gene	Chr6:111242296-111269843 (-)
AKR/J	MGP_AKRJ_G0031013	protein coding gene	Chr6:114229259-114257753 (-)
BALB/cJ	MGP_BALBcJ_G0031093	protein coding gene	Chr6:111186919-111214297 (-)
C3H/HeJ	MGP_C3HHeJ_G0030615	protein coding gene	Chr6:70041866-70069240 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031552	protein coding gene	Chr6:118665409-118697236 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028716	protein coding gene	Chr6:108249490-108277323 (-)
CAST/EiJ	MGP_CASTEiJ_G0030200	protein coding gene	Chr6:114655553-114688517 (-)
CBA/J	MGP_CBAJ_G0030779	protein coding gene	Chr6:123346082-123376432 (-)
DBA/2J	MGP_DBA2J_G0030932	protein coding gene	Chr6:110326045-110353388 (-)
FVB/NJ	MGP_FVBNJ_G0030886	protein coding gene	Chr6:109317951-109346518 (-)
LP/J	MGP_LPJ_G0031012	protein coding gene	Chr6:115709083-115738889 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030920	protein coding gene	Chr6:127627637-127658881 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031579	protein coding gene	Chr6:114243805-114271645 (-)
PWK/PhJ	MGP_PWKPhJ_G0029916	protein coding gene	Chr6:109270750-109299017 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029744	protein coding gene	Chr6:113062551-113092092 (-)
WSB/EiJ	MGP_WSBEiJ_G0030284	protein coding gene	Chr6:114618348-114645790 (-)

Human Ortholog

LHFPL4, LHFPL tetraspan subfamily member 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LHFPL4, LHFPL tetraspan subfamily member 4
Synonyms

GARLH4
Links

HGNC:29568

NCBI Gene ID: 375323

neXtProt AC: NX_Q7Z7J7

UniProt: Q7Z7J7
Chr Location

3p25.3; chr3:9498361-9553822 (-) GRCh38

MGI Vertebrate Homology

Lhfpl4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LHFPL4
Gene Tree

Lhfpl4

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

8
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Lhfpl4
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects inhibitory postsynaptic currents in the hippocampus.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

12
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lhfpl4

ZFIN lhfpl4a

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS39591.1

Ensembl

ENSMUSG00000042873 (Evidence)
NCBI Gene

269788

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042873	Ensembl Gene Model \| MGI Sequence Detail	27295	C57BL/6J	± kb
transcript	ENSMUST00000162280	Ensembl \| MGI Sequence Detail	4762	Not Applicable
polypeptide	ENSMUSP00000124470	Ensembl \| MGI Sequence Detail	247	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009788 LHFPL tetraspan subfamily member 4 protein

(term hierarchy)
InterPro Domains

IPR019372 Lipoma HMGIC fusion partner-like protein

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 4

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MGI:1916164, MGI:2141454

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lhfpl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62432	Chr6:113172341-113172348 (-)	0 bp
Tssr62431	Chr6:113172287-113172323 (-)	40 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24