Rnase9 MGI Mouse Gene Detail - MGI:3057273 - ribonuclease, RNase A family, 9 (non-active)

Symbol

Rnase9
Name

ribonuclease, RNase A family, 9 (non-active)

Feature Type

protein coding gene
IDs

MGI:3057273
NCBI Gene: 328401
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:51275916-51279326 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.35 cM, cytoband B-C1
Mapping Data

2 experiments

SNPs within 2kb

174 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3057273	protein coding gene	Chr14:51275916-51279360 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021267	protein coding gene	Chr14:44985773-44989185 (-)
A/J	MGP_AJ_G0021221	protein coding gene	Chr14:43639161-43642573 (-)
AKR/J	MGP_AKRJ_G0021197	protein coding gene	Chr14:45288493-45291905 (-)
BALB/cJ	MGP_BALBcJ_G0021224	protein coding gene	Chr14:43762564-43765976 (-)
C3H/HeJ	MGP_C3HHeJ_G0021006	protein coding gene	Chr14:45110934-45114346 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021661	protein coding gene	Chr14:46848896-46852306 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019213	protein coding gene	Chr14:42974771-42978151 (-)
CAST/EiJ	MGP_CASTEiJ_G0020530	protein coding gene	Chr14:42185859-42189259 (-)
CBA/J	MGP_CBAJ_G0020973	protein coding gene	Chr14:48302988-48306400 (-)
DBA/2J	MGP_DBA2J_G0021097	protein coding gene	Chr14:43533543-43536953 (-)
FVB/NJ	MGP_FVBNJ_G0021078	protein coding gene	Chr14:43158500-43161912 (-)
LP/J	MGP_LPJ_G0021165	protein coding gene	Chr14:45277332-45280744 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021106	protein coding gene	Chr14:47793859-47797271 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021690	protein coding gene	Chr14:44770628-44774040 (-)
PWK/PhJ	MGP_PWKPhJ_G0020280	protein coding gene	Chr14:40437331-40440743 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020105	protein coding gene	Chr14:40945288-40948655 (-)
WSB/EiJ	MGP_WSBEiJ_G0020583	protein coding gene	Chr14:44974053-44977463 (-)

Human Ortholog

RNASE9, ribonuclease A family member 9 (inactive)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASE9, ribonuclease A family member 9 (inactive)
Synonyms

h461, HEL128, RAK1
Links

HGNC:20673

NCBI Gene ID: 390443

neXtProt AC: NX_P60153

UniProt: P60153
Chr Location

14q11.2; chr14:20556093-20561047 (-) GRCh38

MGI Vertebrate Homology

Rnase9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNASE9
Gene Tree

Rnase9

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

6
Genomic Mutations

1 involving Rnase9
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a null allele are viable, fertile and overtly normal. However, male homozygotes display impaired sperm maturation during epididymal transit.

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

4
CCDS

CCDS36909.1

Ensembl

ENSMUSG00000052382 (Evidence)
NCBI Gene

328401

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052382	Ensembl Gene Model \| MGI Sequence Detail	3411	C57BL/6J	± kb
transcript	ENSMUST00000064214	Ensembl \| MGI Sequence Detail	1189	Not Applicable
polypeptide	ENSMUSP00000066637	Ensembl \| MGI Sequence Detail	184	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014052 ribonuclease-like protein 9

(term hierarchy)
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily
GlyGen

P60154 2 sites

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:93827 Penttinen J, et al., Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. Mol Endocrinol. 2003 Nov;17(11):2138-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnase9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128397	Chr14:51279507-51279529 (-)	-192 bp
Tssr128396	Chr14:51279380-51279385 (-)	-57 bp
Tssr128395	Chr14:51279318-51279336 (-)	-1 bp
Tssr128394	Chr14:51276820-51276826 (-)	2,503 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24