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Fbxw15 Gene Detail
Summary
  • Symbol
    Fbxw15
  • Name
    F-box and WD-40 domain protein 15
  • Synonyms
    Fbxo12J
  • Feature Type
    protein coding gene
  • IDs
    MGI:3505701
    NCBI Gene: 382105
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:109381670-109397330 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3505701
 protein coding gene Chr9:109381670-109397330 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035333
 protein coding gene Chr9:111594239-111681631 (-)
A/J MGP_AJ_G0035314
 protein coding gene Chr9:107522835-107538576 (-)
AKR/J MGP_AKRJ_G0035245
 protein coding gene Chr9:110179987-110209241 (-)
BALB/cJ MGP_BALBcJ_G0035302
 protein coding gene Chr9:106722097-107387727 (-)
C3H/HeJ MGP_C3HHeJ_G0035017
 protein coding gene Chr9:110636160-110654125 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035829
 protein coding gene Chr9:114610339-114626559 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0034984
 protein coding gene Chr9:118757842-118804933 (-)
DBA/2J MGP_DBA2J_G0035143
 protein coding gene Chr9:106874274-107112812 (-)
FVB/NJ MGP_FVBNJ_G0035092
 protein coding gene Chr9:105809242-105827574 (-)
LP/J MGP_LPJ_G0035222
 protein coding gene Chr9:111841250-111999454 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0035849
 protein coding gene Chr9:110503401-110520797 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Synonyms
    FBW12, FBXO12, FBXO35
  • Links
    NCBI Gene ID: 285231
    neXtProt AC: NX_Q6X9E4
    UniProt: Q6X9E4

  • Chr Location
    3p21.31; chr3:48372219-48401259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382105 NCBI Gene Model | MGI Sequence Detail 15661 C57BL/6J ±  kb
    transcript NM_199036 RefSeq | MGI Sequence Detail 1520 C57BL/6  
    polypeptide L7N1X6 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR052121 F-box Protein Family Substrate Recognition Components
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 1
    References
    more
    • Summaries
      All 19
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:93441 Jin J, et al., Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Dec 1;18(21):2573-80
    • Latest
      J:348425 Pham AH, et al., Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024;13(10):802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory