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Fbxw18 Gene Detail
Summary
  • Symbol
    Fbxw18
  • Name
    F-box and WD-40 domain protein 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:3505704
    NCBI Gene: 546161
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:109505802-109531768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    780 from dbSNP Build 142
  • Strain Annotations
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3505704
 protein coding gene Chr9:109505800-109531768 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0035832
 protein coding gene Chr9:114776251-114815173 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0035852
 protein coding gene Chr9:110663692-110688077 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW12, F-box and WD repeat domain containing 12
  • Synonyms
    FBW12, FBXO12, FBXO35
  • Links
    NCBI Gene ID: 285231
    neXtProt AC: NX_Q6X9E4
    UniProt: Q6X9E4

  • Chr Location
    3p21.31; chr3:48372219-48401259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074059 Ensembl Gene Model | MGI Sequence Detail 25967 C57BL/6J ±  kb
    transcript ENSMUST00000098359 Ensembl | MGI Sequence Detail 1519 Not Applicable  
    polypeptide ENSMUSP00000095962 Ensembl | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR052121 F-box Protein Family Substrate Recognition Components
      IPR036322 WD40-repeat-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3034520
    References
    more
    • Summaries
      All 17
      Gene Ontology 1
      Phenotypes 3
    • Earliest
      J:93441 Jin J, et al., Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Dec 1;18(21):2573-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory