Fcho2 MGI Mouse Gene Detail - MGI:3505790

Symbol

Fcho2
Name

FCH domain only 2
Synonyms

5832424M12Rik

Feature Type

protein coding gene
IDs

MGI:3505790
NCBI Gene: 218503
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:98859911-98951957 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 52.16 cM
Mapping Data

1 experiment

SNPs within 2kb

1863 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3505790	protein coding gene	Chr13:98859911-98953085 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020870	protein coding gene	Chr13:100461131-100567200 (-)
A/J	MGP_AJ_G0020824	protein coding gene	Chr13:96632496-96725425 (-)
AKR/J	MGP_AKRJ_G0020798	protein coding gene	Chr13:99578772-99676745 (-)
BALB/cJ	MGP_BALBcJ_G0020822	protein coding gene	Chr13:97339034-97431417 (-)
C3H/HeJ	MGP_C3HHeJ_G0020613	protein coding gene	Chr13:99323165-99422883 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021256	protein coding gene	Chr13:103469695-103571986 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018825	protein coding gene	Chr13:92363720-92458583 (-)
CAST/EiJ	MGP_CASTEiJ_G0020131	protein coding gene	Chr13:98683441-98796115 (-)
CBA/J	MGP_CBAJ_G0020573	protein coding gene	Chr13:107586687-107703132 (-)
DBA/2J	MGP_DBA2J_G0020698	protein coding gene	Chr13:96397966-96490926 (-)
FVB/NJ	MGP_FVBNJ_G0020679	protein coding gene	Chr13:95147329-95242949 (-)
LP/J	MGP_LPJ_G0020773	protein coding gene	Chr13:100567244-100667929 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020707	protein coding gene	Chr13:107915256-108023933 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021297	protein coding gene	Chr13:99026021-99124237 (-)
PWK/PhJ	MGP_PWKPhJ_G0019884	protein coding gene	Chr13:95205860-95303764 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019707	protein coding gene	Chr13:95334037-95432837 (-)
WSB/EiJ	MGP_WSBEiJ_G0020189	protein coding gene	Chr13:99473441-99572154 (-)

Human Ortholog

FCHO2, FCH and mu domain containing endocytic adaptor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCHO2, FCH and mu domain containing endocytic adaptor 2
Links

HGNC:25180

NCBI Gene ID: 115548

neXtProt AC: NX_Q0JRZ9

UniProt: Q0JRZ9
Chr Location

5q13.2; chr5:72956041-73090522 (+) GRCh38

MGI Vertebrate Homology

Fcho2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FCHO2
Gene Tree

Fcho2

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

98
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fcho2

ZFIN fcho2

less

All Sequences

68
RefSeq

5
UniProt

7
CCDS

CCDS56897.1

Ensembl

ENSMUSG00000041685 (Evidence)
NCBI Gene

218503

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041685	Ensembl Gene Model \| MGI Sequence Detail	92047	C57BL/6J	± kb
transcript	ENSMUST00000040340	Ensembl \| MGI Sequence Detail	5122	Not Applicable
polypeptide	ENSMUSP00000042959	Ensembl \| MGI Sequence Detail	809	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000007436 F-BAR domain only protein 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR036168 AP-2 complex subunit mu, C-terminal superfamily

IPR031160 F-BAR domain

IPR030122 F-BAR domain only protein 2, F-BAR domain

IPR001060 FCH domain

IPR028565 Mu homology domain

IPR018808 Muniscin, C-terminal
GlyGen

Q3UQN2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

less

All nucleic 98

cDNA 98

Microarray probesets 4

less

MGI:3035164

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 10
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fcho2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123655	Chr13:98952092-98952114 (-)	-146 bp
Tssr123654	Chr13:98951916-98951939 (-)	29 bp
Tssr123653	Chr13:98951873-98951910 (-)	65 bp
Tssr123652	Chr13:98951771-98951783 (-)	180 bp
Tssr123651	Chr13:98951729-98951765 (-)	210 bp
Tssr123650	Chr13:98951628-98951709 (-)	288 bp
Tssr123649	Chr13:98949806-98949810 (-)	2,149 bp
Tssr123648	Chr13:98940293-98940316 (-)	11,652 bp
Tssr123647	Chr13:98890839-98890869 (-)	61,103 bp
Tssr123646	Chr13:98862211-98862241 (-)	89,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24