S100a2 Gene Detail

Summary

• Symbol
  S100a2
• Name
  S100 calcium binding protein A2
• Synonyms
  CaN19, EG628324, S100L

• Feature Type
  protein coding gene
• IDs
  MGI:3510999
  NCBI Gene: 628324
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr3:90497554-90498815 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, cytoband F1-F2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  153 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3510999	protein coding gene	Chr3:90467670-90498838 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027473	protein coding gene	Chr3:90920187-90921448 (+)
A/J	MGP_AJ_G0027437	protein coding gene	Chr3:87886573-87887887 (+)
AKR/J	MGP_AKRJ_G0027402	protein coding gene	Chr3:90049807-90051069 (+)
BALB/cJ	MGP_BALBcJ_G0027446	protein coding gene	Chr3:87843378-87844661 (+)
C3H/HeJ	MGP_C3HHeJ_G0027188	protein coding gene	Chr3:90214973-90216233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027892	protein coding gene	Chr3:94325253-94326511 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025245	protein coding gene	Chr3:83388616-83389866 (+)
CAST/EiJ	MGP_CASTEiJ_G0026634	protein coding gene	Chr3:90609935-90611188 (+)
CBA/J	MGP_CBAJ_G0027163	protein coding gene	Chr3:97533483-97534744 (+)
DBA/2J	MGP_DBA2J_G0027300	protein coding gene	Chr3:87252767-87254024 (+)
FVB/NJ	MGP_FVBNJ_G0027268	protein coding gene	Chr3:85582805-85584067 (+)
LP/J	MGP_LPJ_G0027409	protein coding gene	Chr3:91977590-91978850 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027289	protein coding gene	Chr3:103774876-103776137 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027951	protein coding gene	Chr3:89799916-89801173 (+)
PWK/PhJ	MGP_PWKPhJ_G0026368	protein coding gene	Chr3:87151350-87152608 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026188	protein coding gene	Chr3:88977886-88978942 (+)
WSB/EiJ	MGP_WSBEiJ_G0026716	protein coding gene	Chr3:90204156-90205413 (+)

Homology

• Human Ortholog
  S100A2, S100 calcium binding protein A2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  S100A2, S100 calcium binding protein A2
  
• Synonyms
  CAN19, S100L
• Links
  HGNC:10492

  NCBI Gene ID: 6273

  neXtProt AC: NX_P29034

  UniProt: P29034

  
  
• Chr Location
  1q21.3; chr1:153561108-153567890 (-)  GRCh38

---

• MGI Vertebrate Homology
  S100a2 stringent orthology
  1 human;1 mouse;2 zebrafish
  
• HCOP
  vertebrate homology predictions: S100A2
• Gene Tree
  S100a2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving S100a2
• Find Mice (IMSR)
  2 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  5
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS57224.1

• Ensembl
  ENSMUSG00000094018 (Evidence)
• NCBI Gene
  628324

Representative Sequences			Length	Strain/Species
genomic	628324	NCBI Gene Model | MGI Sequence Detail	1262	C57BL/6J
transcript	NM_001195760	RefSeq | MGI Sequence Detail	315	ZRU/MplStud
polypeptide	NP_001182689	RefSeq | MGI Sequence Detail	104	ZRU/MplStud

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR011992 EF-hand domain pair
  IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:3646384

References

• Summaries
  All 17

  Diseases 1

  Gene Ontology 2

  Phenotypes 4
• Earliest
  J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for S100a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30231	Chr3:90495843-90495857 (+)	-1,704 bp
Tssr30232	Chr3:90497014-90497024 (+)	-535 bp