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Foxi3 Gene Detail
Summary
  • Symbol
    Foxi3
  • Name
    forkhead box I3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3511278
    NCBI Gene: 232077
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:70933590-70938050 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3511278
 protein coding gene Chr6:70933515-70938050 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030851
 protein coding gene Chr6:71399677-71404196 (+)
A/J MGP_AJ_G0030821
 protein coding gene Chr6:68664458-68668979 (+)
AKR/J MGP_AKRJ_G0030750
 protein coding gene Chr6:70643131-70647653 (+)
BALB/cJ MGP_BALBcJ_G0030832
 protein coding gene Chr6:68695140-68699659 (+)
C3H/HeJ MGP_C3HHeJ_G0030880
 protein coding gene Chr6:113614679-113619210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031290
 protein coding gene Chr6:73282087-73286620 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028479
 protein coding gene Chr6:67851494-67855940 (+)
CAST/EiJ MGP_CASTEiJ_G0029940
 protein coding gene Chr6:70478632-70483175 (+)
CBA/J MGP_CBAJ_G0030519
 protein coding gene Chr6:76178726-76183259 (+)
DBA/2J MGP_DBA2J_G0030671
 protein coding gene Chr6:68038971-68043488 (+)
FVB/NJ MGP_FVBNJ_G0030624
 protein coding gene Chr6:67408320-67412843 (+)
LP/J MGP_LPJ_G0030750
 protein coding gene Chr6:71331902-71336427 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030659
 protein coding gene Chr6:79702752-79707274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031316
 protein coding gene Chr6:70479711-70484230 (+)
PWK/PhJ MGP_PWKPhJ_G0029656
 protein coding gene Chr6:66896520-66901177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029484
 protein coding gene Chr6:69197903-69203951 (+)
WSB/EiJ MGP_WSBEiJ_G0030022
 protein coding gene Chr6:70812395-70816916 (+)



Homology
more
  • Human Ortholog
    FOXI3, forkhead box I3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXI3, forkhead box I3
  • Synonyms
    CFM2
  • Links
    NCBI Gene ID: 344167
    neXtProt AC: NX_A8MTJ6
    UniProt: A8MTJ6

  • Chr Location
    2p11.2; chr2:88446787-88452693 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxi3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 5 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice start dying after E9.5. Those born die neonatally, lack a mouth and whiskers, and show branchial arch-derived skeletal defects, including a reduced mandible, total absence of inner, middle and external ear structures, and increased cranial neural crest cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    100
  • cDNA Data
    4
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232077 NCBI Gene Model | MGI Sequence Detail 4461 C57BL/6J ±  kb
    transcript NM_001101464 RefSeq | MGI Sequence Detail 1206 mixed  
    polypeptide D3Z120 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 4
      Primer pair 2
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:93815 Ohyama T, et al., Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn. 2004 Nov;231(3):640-6
    • Latest
      J:344153 Raymundo JR, et al., KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions and their impairment causes aplasia cutis. J Clin Invest. 2023 Dec 19;:e174138
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory