Rnase12 MGI Mouse Gene Detail - MGI:3528588 - ribonuclease, RNase A family, 12 (non-active)

Symbol

Rnase12
Name

ribonuclease, RNase A family, 12 (non-active)

Feature Type

protein coding gene
IDs

MGI:3528588
NCBI Gene: 497106
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:51294155-51294699 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.36 cM, cytoband B-C1
Mapping Data

1 experiment

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3528588	protein coding gene	Chr14:51294155-51295118 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021269	protein coding gene	Chr14:45006172-45006716 (-)
A/J	MGP_AJ_G0021223	protein coding gene	Chr14:43658198-43658742 (-)
AKR/J	MGP_AKRJ_G0021199	protein coding gene	Chr14:45306946-45307490 (-)
BALB/cJ	MGP_BALBcJ_G0021226	protein coding gene	Chr14:43782086-43782630 (-)
C3H/HeJ	MGP_C3HHeJ_G0021008	protein coding gene	Chr14:45131160-45131704 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021663	protein coding gene	Chr14:46869149-46869693 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019215	protein coding gene	Chr14:42993386-42993930 (-)
CAST/EiJ	MGP_CASTEiJ_G0020532	protein coding gene	Chr14:42204553-42205097 (-)
CBA/J	MGP_CBAJ_G0020975	protein coding gene	Chr14:48321442-48321986 (-)
DBA/2J	MGP_DBA2J_G0021099	protein coding gene	Chr14:43552516-43553060 (-)
FVB/NJ	MGP_FVBNJ_G0021080	protein coding gene	Chr14:43179387-43179931 (-)
LP/J	MGP_LPJ_G0021167	protein coding gene	Chr14:45297776-45298320 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021108	protein coding gene	Chr14:47813613-47814157 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021692	protein coding gene	Chr14:44789096-44789640 (-)
PWK/PhJ	MGP_PWKPhJ_G0020282	protein coding gene	Chr14:40456053-40456597 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020107	protein coding gene	Chr14:40963577-40964121 (-)
WSB/EiJ	MGP_WSBEiJ_G0020585	protein coding gene	Chr14:44993362-44993906 (-)

Human Ortholog

RNASE12, ribonuclease A family member 12 (inactive)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASE12, ribonuclease A family member 12 (inactive)
Synonyms

HEL-S-85p, RAI1
Links

HGNC:24211

NCBI Gene ID: 493901

neXtProt AC: NX_Q5GAN4

UniProt: Q5GAN4
Chr Location

14q11.2; chr14:20590073-20591376 (-) GRCh38

MGI Vertebrate Homology

Rnase12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNASE12
Gene Tree

Rnase12

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Genomic Mutations

1 involving Rnase12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS27032.1

Ensembl

ENSMUSG00000068407 (Evidence)
NCBI Gene

497106

			Length	Strain/Species	Flank
genomic	497106	NCBI Gene Model \| MGI Sequence Detail	545	C57BL/6J	± kb
transcript	NM_001011875	RefSeq \| MGI Sequence Detail	545	Not Specified
polypeptide	Q5GAM8	UniProt \| EBI \| MGI Sequence Detail	145	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014044 ribonuclease-like protein 12

(term hierarchy)
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 24

Gene Ontology 4

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnase12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128406	Chr14:51295131-51295146 (-)	-440 bp
Tssr128405	Chr14:51295096-51295124 (-)	-411 bp
Tssr128404	Chr14:51295068-51295085 (-)	-378 bp
Tssr128403	Chr14:51295052-51295063 (-)	-359 bp
Tssr128402	Chr14:51294937-51294944 (-)	-242 bp
Tssr128401	Chr14:51294923-51294930 (-)	-228 bp
Tssr128400	Chr14:51294718-51294745 (-)	-33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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