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Aox2 Gene Detail
Summary
  • Symbol
    Aox2
  • Name
    aldehyde oxidase 2
  • Synonyms
    Aoh3, Aox3l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3529596
    NCBI Gene: 213043
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58317485-58418423 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 29.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3529596
 protein coding gene Chr1:58317485-58419418 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016048
 protein coding gene Chr1:58128195-58236821 (+)
A/J MGP_AJ_G0016031
 protein coding gene Chr1:56103901-56202698 (+)
AKR/J MGP_AKRJ_G0015987
 protein coding gene Chr1:57612995-57721063 (+)
BALB/cJ MGP_BALBcJ_G0015986
 protein coding gene Chr1:56143750-56238019 (+)
C3H/HeJ MGP_C3HHeJ_G0015818
 protein coding gene Chr1:57888608-57985370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016439
 protein coding gene Chr1:60489943-60586725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014161
 protein coding gene Chr1:52047825-52135337 (+)
CAST/EiJ MGP_CASTEiJ_G0015400
 protein coding gene Chr1:57138701-57236463 (+)
CBA/J MGP_CBAJ_G0015790
 protein coding gene Chr1:62256620-62365522 (+)
DBA/2J MGP_DBA2J_G0015891
 protein coding gene Chr1:55507977-55601333 (+)
FVB/NJ MGP_FVBNJ_G0015893
 protein coding gene Chr1:54844234-54942187 (+)
LP/J MGP_LPJ_G0015963
 protein coding gene Chr1:59025813-59137677 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015913
 protein coding gene Chr1:65256840-65358235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016486
 protein coding gene Chr1:57604280-57698148 (+)
PWK/PhJ MGP_PWKPhJ_G0015186
 protein coding gene Chr1:54898458-54990110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014967
 protein coding gene Chr1:57185223-57281459 (+)
WSB/EiJ MGP_WSBEiJ_G0015463
 protein coding gene Chr1:57274775-57387136 (+)



Homology
more
  • Human Ortholog
    AOX2P, aldehyde oxidase 2, pseudogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AOX2P, aldehyde oxidase 2, pseudogene
  • Synonyms
    AOH2, AOX2, AOX3L1
  • Links
    NCBI Gene ID: 344454

  • Chr Location
    2q33.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 213043 NCBI Gene Model | MGI Sequence Detail 100939 C57BL/6J ±  kb
transcript NM_001008419 RefSeq | MGI Sequence Detail 4776 ZRU/MplStud  
polypeptide Q5SGK3 UniProt | EBI | MGI Sequence Detail 1345 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    1.17.3.-, 1.2.3.1
  • InterPro Domains
    IPR002888 [2Fe-2S]-binding
    IPR036884 [2Fe-2S]-binding domain superfamily
    IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
    IPR036010 2Fe-2S ferredoxin-like superfamily
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR014313 Aldehyde oxidase
    IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
    IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
    IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
    IPR016208 Aldehyde oxidase/xanthine dehydrogenase-like
    IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
    IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain
    IPR012675 Beta-grasp domain superfamily
    IPR005107 CO dehydrogenase flavoprotein, C-terminal
    IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
    IPR016166 FAD-binding domain, PCMH-type
    IPR036318 FAD-binding, type PCMH-like superfamily
    IPR016167 FAD-binding, type PCMH, subdomain 1
    IPR016169 FAD-binding, type PCMH, subdomain 2
    IPR002346 Molybdopterin dehydrogenase, FAD-binding
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:228048 Kurosaki M, et al., Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Cell Mol Life Sci. 2013 May;70(10):1807-30
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory