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Serpinb3a Gene Detail
Summary
  • Symbol
    Serpinb3a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
  • Synonyms
    Scca2, Serpinb4, Sqn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3573933
    NCBI Gene: 20248
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106973317-106980033 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3573933
 protein coding gene Chr1:106973317-106980033 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016377
 protein coding gene Chr1:109253752-109259070 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0016321
 protein coding gene Chr1:108302403-108308260 (-)
BALB/cJ MGP_BALBcJ_G0016318
 protein coding gene Chr1:105764970-105797946 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016776
 protein coding gene Chr1:113395182-113409680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014495
 protein coding gene Chr1:99744826-99750620 (-)
CAST/EiJ MGP_CASTEiJ_G0015726
 protein coding gene Chr1:107672510-107948255 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0016224
 protein coding gene Chr1:104719290-104725545 (-)
FVB/NJ MGP_FVBNJ_G0016223
 protein coding gene Chr1:103409817-103682867 (-)
LP/J MGP_LPJ_G0016296
 protein coding gene Chr1:110443287-110449898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016249
 protein coding gene Chr1:121685785-121696600 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016815
 protein coding gene Chr1:108378111-108384728 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015301
 protein coding gene Chr1:107041749-107047733 (-)
WSB/EiJ MGP_WSBEiJ_G0015790
 protein coding gene Chr1:108484106-108487964 (-)



Homology
more
  • Human Ortholog
    SERPINB3, serpin family B member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB3, serpin family B member 3
  • Synonyms
    HsT1196, SCC, SCCA-1, SCCA1, SCCA-PD, SSCA1, T4-A
  • Links
    NCBI Gene ID: 6317
    neXtProt AC: NX_P29508
    UniProt: P29508

  • Chr Location
    18q21.33; chr18:63655197-63661893 (-)  GRCh38
  • Human Ortholog
    SERPINB4, serpin family B member 4
  • Synonyms
    LEUPIN, PI11, SCCA1, SCCA-2, SCCA2
  • Links
    NCBI Gene ID: 6318
    neXtProt AC: NX_P48594
    UniProt: P48594

  • Chr Location
    18q21.33; chr18:63637259-63644256 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20248 NCBI Gene Model | MGI Sequence Detail 6717 C57BL/6J ±  kb
transcript NM_009126 RefSeq | MGI Sequence Detail 1629 C57BL/6  
polypeptide NP_033152 RefSeq | MGI Sequence Detail 387 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    Genomic 1
    cDNA 5

    Microarray probesets 7
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:335153 Qiu T, et al., Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory