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Tatdn2 Gene Detail
Summary
  • Symbol
    Tatdn2
  • Name
    TatD DNase domain containing 2
  • Synonyms
    mKIAA0218
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576210
    NCBI Gene: 381801
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113674090-113688030 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576210
 protein coding gene Chr6:113674011-113688030 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031135
 protein coding gene Chr6:116242748-116257208 (+)
A/J MGP_AJ_G0031104
 protein coding gene Chr6:111777250-111791264 (+)
AKR/J MGP_AKRJ_G0031035
 protein coding gene Chr6:114781974-114797492 (+)
BALB/cJ MGP_BALBcJ_G0031115
 protein coding gene Chr6:111722647-111736666 (+)
C3H/HeJ MGP_C3HHeJ_G0030593
 protein coding gene Chr6:69498847-69515442 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031574
 protein coding gene Chr6:119240196-119254718 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028738
 protein coding gene Chr6:108802877-108818611 (+)
CAST/EiJ MGP_CASTEiJ_G0030222
 protein coding gene Chr6:115239478-115254499 (+)
CBA/J MGP_CBAJ_G0030801
 protein coding gene Chr6:123951403-123965415 (+)
DBA/2J MGP_DBA2J_G0030954
 protein coding gene Chr6:110857571-110871898 (+)
FVB/NJ MGP_FVBNJ_G0030908
 protein coding gene Chr6:109862003-109876060 (+)
LP/J MGP_LPJ_G0031034
 protein coding gene Chr6:116266113-116280117 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030942
 protein coding gene Chr6:128196319-128210332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031601
 protein coding gene Chr6:114800406-114815317 (+)
PWK/PhJ MGP_PWKPhJ_G0029938
 protein coding gene Chr6:109819478-109833812 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029766
 protein coding gene Chr6:113606486-113622750 (+)
WSB/EiJ MGP_WSBEiJ_G0030306
 protein coding gene Chr6:115176335-115190352 (+)



Homology
more
  • Human Ortholog
    TATDN2, TatD DNase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TATDN2, TatD DNase domain containing 2
  • Links
    NCBI Gene ID: 9797
    neXtProt AC: NX_Q93075
    UniProt: Q93075

  • Chr Location
    3p25.3; chr3:10248023-10281218 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    33
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381801 NCBI Gene Model | MGI Sequence Detail 13941 C57BL/6J ±  kb
transcript NR_177929 RefSeq | MGI Sequence Detail 3298 ZRU/MplStud  
polypeptide NP_001334285 RefSeq | MGI Sequence Detail 783 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR001130 3'-5' ssDNA/RNA exonuclease TatD-like
    IPR018228 Deoxyribonuclease, TatD-related, conserved site
    IPR032466 Metal-dependent hydrolase
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141456
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory